Modification of Sodium, Glucose, Potassium, and Osmolarity in Packed Red Blood Cells and Fresh Frozen Plasma Using a Desktop Hemoconcentrator Setup

Striker, Carrie Whittaker; Woldorf, Stacia; Holt, David W.

doi:10.1051/ject/201244060

J Extra Corpor Technol

2012

DOI: 10.1051/ject/201244060

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Modification of Sodium, Glucose, Potassium, and Osmolarity in Packed Red Blood Cells and Fresh Frozen Plasma Using a Desktop Hemoconcentrator Setup

Carrie Whittaker Striker¹,

Stacia Woldorf²,

David W. Holt³

Abstract: Massive transfusion with packed blood cells (PRBCs) or fresh frozen plasma (FFP) can result in dangerous complications including stroke, kidney failure, and cardiac arrest. A simple, bench top technique using a hemoconcentrator and dialysate solution is described to correct critical values of sodium, glucose, potassium, and osmolarity in PRBCs and FFP. Sodium, glucose, and osmolarity were corrected to normal or near normal values. Elevated potassium was reduced by 65%, but not completely normalized. A simple, … Show more

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Cited by 5 publications

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Trauma‐related electrolyte disturbances: From resuscitation to rhabdomyolysis

Fredrickson

Carver

2022

Nut in Clin Prac

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Traumatic injury results in drastic changes to a patient's normal physiology. The hormonal stress response, as well as some treatment strategies, lead to significant disruptions in electrolyte homeostasis that are important for clinicians to understand. In addition, advances in fluid resuscitation and modern transfusion practices have led to their own unique set of consequences, which we are just beginning to appreciate. Special attention is placed on rhabdomyolysis, as this distinct entity represents an extreme example of injury induced electrolyte derangements. This review describes the physiologic response to trauma and highlights some of the important electrolyte abnormalities that can be encountered while caring for the injured patient.

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Trauma‐related electrolyte disturbances: From resuscitation to rhabdomyolysis

Fredrickson

Carver

2022

Nut in Clin Prac

View full text Add to dashboard Cite

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New frontiers in neonatal red blood cell transfusion research

Stark,

Juul

2023

J Perinatol

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Zero‐balance ultrafiltration of the priming blood modifies the priming components and improves the clinical outcome in infants undergoing cardiopulmonary bypass: A randomized controlled trial

et al. 2019

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Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume‐to‐blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long‐term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonates, it is suggested that the metabolic load and osmolality are diminished before CPB initiation. We conducted the present study to test the hypothesis that the zero‐balance ultrafiltration (Z‐BUF) of the priming blood with 0.45% saline might be sufficient for modifying the metabolic load and osmolality and, thus, achieving a physiological state. Sixty infants with a weight below 10 kg undergoing CPB were randomly assigned either to a control group or to a Z‐BUF group and the Z‐BUF of the priming blood was performed in the latter group. Electrolytes and osmolality were measured in the priming blood. The bleeding volume, the blood transfusion rate, the length of mechanical ventilation, the length of stay in the intensive care unit (ICU), the body temperature, and renal biomarkers were compared between the 2 groups. The osmolality and the levels of potassium, sodium, glucose, chloride, and lactate in the priming blood were significantly decreased after Z‐BUF (P < .01). The Z‐BUF group showed significant reductions in postoperative blood loss; postoperative blood transfusion; time to extubation; the length of stay in the ICU; the levels of lactate, sodium, and blood urea nitrogen at 24 hours postoperatively and the body temperature at 18 hours postoperatively (P < .05). However, no statistically significant differences were found between the 2 groups regarding the body temperature and the levels of serum creatinine and blood urea nitrogen after admission to the ICU. The results of the present study demonstrated that the Z‐BUF of the priming blood could be a useful strategy in infants undergoing CPB insofar as it significantly modified the composition of the priming blood and improved the clinical outcome among our patients.

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Modification of Sodium, Glucose, Potassium, and Osmolarity in Packed Red Blood Cells and Fresh Frozen Plasma Using a Desktop Hemoconcentrator Setup

Cited by 5 publications

References 18 publications

Trauma‐related electrolyte disturbances: From resuscitation to rhabdomyolysis

Trauma‐related electrolyte disturbances: From resuscitation to rhabdomyolysis

New frontiers in neonatal red blood cell transfusion research

Zero‐balance ultrafiltration of the priming blood modifies the priming components and improves the clinical outcome in infants undergoing cardiopulmonary bypass: A randomized controlled trial

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