Modification of the anti-nociceptive activity of morphine by centrally administered ouabain and dopamine

Calcutt, C.R.; Doggett, N.S.; Spencer, P.S.

doi:10.1007/bf00572268

Cited by 33 publications

(10 citation statements)

References 6 publications

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“…In our prior studies in CD-1 mice, (Ϫ)-sulpiride did not reproduce the actions of haloperidol. However, in other mouse strains and models, dopamine D 2 receptors can influence opioid action (Calcutt et al, 1971;Kunihara et al, 1993;Kamei and Saitoh, 1996), a finding that was supported in a more recent study looking at opioid actions in a dopamine D 2 receptor knockout mouse (King et al, 2001). Although there may be situations in which D 2 receptors modulate opioid actions, 1 systems also are important.…”

Section: Discussionmentioning

confidence: 89%

Modulation of Brainstem Opiate Analgesia in the Rat by σ₁Receptors: A Microinjection Study

Mei¹,

Pasternak²

2007

J Pharmacol Exp Ther

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ABSTRACT1 Receptors have been implicated in the modulation of opioid analgesia. In the current study, we examined the role of 1 systems in the periaqueductal gray (PAG), the rostroventral medulla (RVM), and the locus coeruleus (LC) of the rat, regions previously shown to be sensitive to morphine. Morphine was a potent analgesic in all three regions. Coadministration of the 1 agonist (ϩ)-pentazocine diminished the analgesic actions of morphine in all three regions, although the PAG was far less sensitive than the other two regions. Blockade of the 1 receptors with haloperidol in the RVM markedly enhanced the analgesic actions of coadministered morphine, implying a tonic activity of the 1 system in this region. This effect was mimicked by down-regulation of RVM 1 receptors using an antisense approach. However, no tonic 1 activity was observed in either the LC or the PAG. The RVM also was important in modulating analgesia elicited from morphine microinjected into the PAG. The analgesic actions of morphine given into the PAG could be attenuated by (ϩ)-pentazocine placed into the RVM, whereas haloperidol in the RVM enhanced PAG morphine analgesia. These studies illustrate the pharmacological importance of 1 receptors in the brainstem modulation of opioid analgesia.Receptors are unique proteins of approximately 28 kDa that have been cloned from guinea pigs (Hanner et al

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Section: Discussionmentioning

confidence: 89%

Modulation of Brainstem Opiate Analgesia in the Rat by σ₁Receptors: A Microinjection Study

Mei¹,

Pasternak²

2007

J Pharmacol Exp Ther

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“…In fact, the only study that has evaluated previously the effect of i.c.v. ouabain on morphine-induced antinociception found that 100 ng of ouabain did not antagonize the effect of morphine (Calcutt et al, 1971). On the other hand, 10 ng/rat ouabain i.t.…”

Section: Discussionmentioning

confidence: 96%

Role of Na⁺,K⁺-ATPase in Morphine-Induced Antinociception

Masocha

Horváth

Agil

et al. 2003

J Pharmacol Exp Ther

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“…Reduction of morphine analgesia has been demonstrated 0300-9564/81/0051/0213/8 02.00 following administration of several drugs, which decrease central DA levels, such as 6-hydroxydopamine (Nakamura et aI, 1973) and alpha-methyl-p-tyrosine (Verri et al, 1968). On the other hand, it has been shown that DA administered by intracerebroventricular injection in large doses antagonized the morphine analgesia (Calcutt et al, 1971). In addition, DA receptor stimulation reduced, while DA receptor blockade enhanced, the antinociceptive effect of vaginal stimulation (Crowley et al, 1977).…”

Section: Introductionmentioning

confidence: 95%

Activation of striatal dopamine receptors induces pain inhibition in rats

Lin

Chandra

et al. 1981

J. Neural Transmission

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In the rat, elevating dopamine content in corpus striatum with electrical stimulation of substantia nigra or direct administration of apomorphine (50-200 micrograms) into the lateral cerebral ventricle or apomorphine (2-10 microgram) into the caudate-putamen complex decreased pain sensitivity (as shown by an increase in the latency to hind-paw lick in the hot plate test). Furthermore, the decreased pain sensitivity after the central administration of apomorphine was antagonized by pretreatment with haloperidol (a dopamine antagonist). On the other hand, lowering dopamine content in corpus striatum with electrolytic destruction of substantia nigra and 6-hydroxydopamine lesions to the substantia nigra, as well as direct injection of haloperidol into the lateral cerebral ventricle or caudate-putamen complex increased pain sensitivity. The data indicate that activation of striatal dopamine receptors in rat brain induces pain inhibition.

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Modification of the anti-nociceptive activity of morphine by centrally administered ouabain and dopamine

Cited by 33 publications

References 6 publications

Modulation of Brainstem Opiate Analgesia in the Rat by σ₁Receptors: A Microinjection Study

Modulation of Brainstem Opiate Analgesia in the Rat by σ₁Receptors: A Microinjection Study

Role of Na⁺,K⁺-ATPase in Morphine-Induced Antinociception

Activation of striatal dopamine receptors induces pain inhibition in rats

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Modification of the anti-nociceptive activity of morphine by centrally administered ouabain and dopamine

Cited by 33 publications

References 6 publications

Modulation of Brainstem Opiate Analgesia in the Rat by σ1Receptors: A Microinjection Study

Modulation of Brainstem Opiate Analgesia in the Rat by σ1Receptors: A Microinjection Study

Role of Na+,K+-ATPase in Morphine-Induced Antinociception

Activation of striatal dopamine receptors induces pain inhibition in rats

Contact Info

Product

Resources

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Modulation of Brainstem Opiate Analgesia in the Rat by σ₁Receptors: A Microinjection Study

Modulation of Brainstem Opiate Analgesia in the Rat by σ₁Receptors: A Microinjection Study

Role of Na⁺,K⁺-ATPase in Morphine-Induced Antinociception