Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes

Kim, Jin Hee; Lee, Mee-Ri; Hong, Yun–Chul

doi:10.1016/j.envres.2016.02.026

Cited by 26 publications

(26 citation statements)

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“…It is known that spermatogenic cells lacking PRDX4 are more susceptible to cell death via oxidative damage than their wild-type counterparts 49 , and that PRDX4 exerts its protective function against oxidative damage by scavenging reactive oxygen species (ROS) in the extracellular space 50 . On the other hand, studies have proven that SOD2 is a biomarker of several types of cancer 51 , 52 and that BPA has the ability to modify SOD2 levels in different cell types 53 , 54 . Therefore, up-regulation of these proteins in 100 µM BPA-treated germ cells could be associated with abnormal cell growth, cellular damage, and cancer.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A Affects on the Functional Properties and Proteome of Testicular Germ Cells and Spermatogonial Stem Cells in vitro Culture Model

Karmakar

Kang

Kim

et al. 2017

Sci Rep

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The endocrine disruptor bisphenol A (BPA) is well known for its adverse effect on male fertility. Growing evidence suggests that BPA may interact with testicular germ cells and cause infertility as a result of its estrogenic activity. Objective of current in vitro study was to investigate the proliferation, survivability and stemness properties of mouse testicular germ cells exposed to BPA, and to evaluate possible expression of cellular proteome. Our results showed that germ cell viability and proliferation were not affected by low concentrations (0.01, 0.1, 1, and 10 µM) although significant reduction observed at 100 µM BPA. Germ cell self-renewal and differentiation related marker proteins expression found unchanged at those concentrations. When BPA-exposed germ cells were transplanted into recipient testes, we observed fewer colonies at higher concentrations (10 and 100 µM). Additionally, a significant frequency of recombination failure during meiosis was observed in 10 µM BPA-exposed germ cell transplanted recipient. Moreover, experiment on continuous BPA-exposed and 100 µM BPA-recovered germ cells suggested that spermatogonial stem cells are more potential to survive in adverse environment. Finally, scrutinizing differentially expressed cellular proteins resulted from our proteomic analysis, we conclude that BPA exposure might be associated with several health risks and infertility.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A Affects on the Functional Properties and Proteome of Testicular Germ Cells and Spermatogonial Stem Cells in vitro Culture Model

Karmakar

Kang

Kim

et al. 2017

Sci Rep

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“…This study estimated the relation between BPA exposure and urinary levels of MDA, an oxidative stress biomarker, in the elderly aged 60 or over recruited from the Korean Elderly Environmental Panel (KEEP) study. Briefly, among a total of 560 elderly people who visited a community elderly welfare center as many as five times for a medical examination (twice in 2008, once in 2009, and twice in 2010) [ 9 ], 548 subjects were included in the analysis after excluding 12 whose blood samples were unavailable.…”

Section: Methodsmentioning

confidence: 99%

“…The ubiquitous exposure to BPA [ 1 ] and its toxic potential [ 2 – 4 ] raise concerns of its adverse effects on both non-sexual and sexual organs [ 5 – 7 ]. Recently, several studies have suggested that oxidative stress is a possible mechanism that establishes the relation between exposure to BPA and adverse health outcomes [ 8 , 9 ]. However, there has been a limited number of reports on the relation between BPA exposure and oxidative stress biomarkers [ 10 – 17 ], particularly for malondialdehyde (MDA) [ 10 – 13 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Increase of urinary malondialdehyde level by bisphenol A exposure: a longitudinal panel study

Kim¹,

Hong²

2017

Environ Health

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BackgroundTo verify oxidative stress as a possible mechanism that establishes a relationship between exposure to bisphenol A (BPA) and adverse health outcomes in the elderly Korean population, we evaluated the relation between visit-to-visit variations in urinary BPA and oxidative stress biomarker.MethodsTo assess the relation between BPA and urinary malondialdehyde (MDA) as an oxidative stress biomarker, we used a mixed effect model after controlling for age, sex, BMI, drinking status, exercise, urinary cotinine level, PM10 on lag day 2, and mean temperature and dew point on the day. The relation between exposure to BPA and MDA level by sex of participants and polymorphisms of oxidative stress-related genes (COX2, EPHX1, HSP70-hom, PON1, eNOS, CAT, DRD2, SOD2, and MPO) was also evaluated.ResultsA significant association was found for BPA with MDA in both male and female elderly participants (male, β = 0.19 and p = 0.0003; female, β = 0.18 and p < .0001; and total, β = 0.18 and p < .0001). Furthermore, the association of BPA with MDA was found regardless of any genotype of the nine oxidative stress-related genes.ConclusionsThe results of our study suggest a strong association of BPA with oxidative stress, not related with sex and oxidative stress-related gene polymorphisms.

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“…Interestingly, we only observed a significant association between bisphenols and endometriosis in the subset of women in the highest TBARS tertile. Although this has not previously been reported in the setting of endometriosis or other gynecological disorders, it has been suggested that genetic polymorphisms of some oxidative-stress-related genes (e.g., cyclooxygenase 2 (COX2), catalase (CAT), and superoxide dismutase (COX2)) may modify the association between BPA exposure and liver function [49]. It has also been proposed that genetic variants of SOD2 might modify the association between urinary concentrations of phthalates and the risk of asthma, which was increased in patients with the TT SOD2 variant (related to higher oxidative stress levels) [50].…”

Section: Discussionmentioning

confidence: 87%

Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

Peinado

Lendínez

Sotelo

et al. 2020

IJERPH

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Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Methods: This case–control study enrolled 124 women between January 2018 and July 2019: 35 women with endometriosis (cases) and 89 women without endometriosis undergoing abdominal surgery for other reasons (controls). Endometriosis was diagnosed (cases) or ruled out (controls) by laparoscopic inspection of the pelvis and the biopsy of suspected lesions (histological diagnosis). Fasting urine samples were collected before surgery to determine concentrations of BPA, BPS, BPF, and TBARS. Associations of bisphenol and TBARS concentrations with endometriosis risk were explored with multivariate logistic and linear regression analyses. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0–2.3] and Σbisphenols [OR 1.5; 95%CI 0.9–2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3–10.3] and Σbisphenols [OR 5.4; 95%CI 1.9–15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0–2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0–4.1] and Σbisphenols [OR 2.2; 95%CI 1.0–4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 μM). Conclusion: Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings.

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Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes

Cited by 26 publications

References 50 publications

Bisphenol A Affects on the Functional Properties and Proteome of Testicular Germ Cells and Spermatogonial Stem Cells in vitro Culture Model

Bisphenol A Affects on the Functional Properties and Proteome of Testicular Germ Cells and Spermatogonial Stem Cells in vitro Culture Model

Increase of urinary malondialdehyde level by bisphenol A exposure: a longitudinal panel study

Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

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