Modification of the Classification of the Eye Changes of Graves' Disease: Recommendations of the Ad Hoc Committee of The American Thyroid Association

Werner, Sidney C.

doi:10.1210/jcem-44-1-203

Cited by 443 publications

(209 citation statements)

References 0 publications

Supporting

Mentioning

195

Contrasting

Unclassified

Order By: Relevance

“…GD diagnosis was determined by the presence of hyperthyroidism and serum anti-thyrotropin receptor antibodies and/or an increased 123 I uptake ratio with diffuse uptake. Ophthalmopathy was classified according to the system recommended by the American Thyroid Association (ATA) Committee [37]. One hundred and three of the GD patients, 24 males and 79 females, showed ophthalmopathy defined as ATA class III or greater and were classified as GO.…”

Section: Subjectsmentioning

confidence: 99%

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

et al. 2006

View full text Add to dashboard Cite

Abstract. Graves' disease (GD) is an autoimmune disorder with genetic predisposition and frequently associated with Graves' ophthalmopathy (GO). Interleukin 12 (IL-12) is an important mediator of inflammatory immune responses and is expressed in the thyroid and orbit. IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33. The aim of the present study was to investigate whether IL-12B gene polymorphism is associated with the development of GD or GO. IL-12B gene polymorphism was studied in Japanese GD patients (n = 329) and healthy control subjects without anti-thyroid autoantibodies or a family history of autoimmune disorders (n = 226). The A/C polymorphism at position 1188 of the 3' untranslated region (3'UTR) of the IL-12B gene was analyzed using the polymerase chain reaction -restriction fragment length polymorphism method. There was no difference in allele or genotype frequency of the IL-12B gene polymorphism (1188A/C) between GD patients and control subjects. There was no association of the IL-12B gene polymorphism with ophthalmopathy, severity of hyperthyroidism or serum IgE levels. There was no association of the IL-12B gene polymorphism with serum IL-12 levels, which were significantly elevated in hyperthyroid phase of GD. In conclusion, IL-12B gene 1188A/C polymorphism is not associated with GD or GO susceptibility in Japanese.

show abstract

Section: Subjectsmentioning

confidence: 99%

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

et al. 2006

View full text Add to dashboard Cite

show abstract

“…As conseqüências da OG e seu tratamento, incluindo avaliação cirúrgica, são na maioria das vezes, avaliadas por meio de medidas biológicas tais como a classificação NOSPECS (21) . Enquanto que medidas biológicas são vitais e provêem informações valiosas para os médicos, elas freqüentemente correlacionam pobremente com a experiência pessoal do paciente em relação à capacidade funcional e percepção de saúde (22) .…”

unclassified

“…Escores menores que três significam oftalmopatia em fase não inflamatória (Tabela 1). Para avaliar as alterações oculares da doença de Graves utilizou-se a classificação "NOSPECS", que permitiu distribuir os pacientes portadores de OG em três categorias: leve ("NOSPECS" 2a, 30-a, 40-a), moderada/grave ("NOSPECS" 2b, 3bc, 4bc) e grave ("NOSPECS" 5bc, 6a-c) (Tabela 2) (21,23) .…”

unclassified

Auto-estima na forma inativa da oftalmopatia de Graves

Magalhães

Pereira

Manso

et al. 2008

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

“…The patients were divided into two subgroups, large ( ‡5 cm) (n=119) or small (<5 cm) (n=78) goiter groups. Patients with TAO were defined by the presence of proptosis [American Thyroid Association (ATA) class 3] or higher ATA class (diplopia, corneal, and optic-nerve involvement) (Werner 1977). GD patients without and with ophthalmopathy were 111 and 88, respectively.…”

Section: Clinical Manifestations Of Graves' Patientsmentioning

confidence: 99%

Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients

et al. 2003

View full text Add to dashboard Cite

As part of a genome scan to locate familial Graves' disease (GD) and Hashimoto's thyroiditis (HT) genes, an autoimmune thyroid disease (AITD) susceptibility locus has recently been identified at 5q31-q33 in a Japanese population. We performed an association study using six microsatellite markers located at this locus in a set of 440 unrelated Japanese AITD patients and 218 Japanese controls. We found significant allelic association between AITD and three markers located in 5q23-q33. GD demonstrated significant associations with two of these markers, while HT did not show significant associations with any markers. Further, when patients with GD were stratified according to clinical manifestations, the association was significantly different from the other subgroup of each category. These findings suggest the presence of susceptible genes of AITD, especially distinct subgroups of GD, in or near 5q23-q33.

show abstract

Modification of the Classification of the Eye Changes of Graves' Disease: Recommendations of the Ad Hoc Committee of The American Thyroid Association

Cited by 443 publications

References 0 publications

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

Auto-estima na forma inativa da oftalmopatia de Graves

Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients

Contact Info

Product

Resources

About