The current study is based on the analysis and adaptation of a Federal Emergency Management Agency guide, FEMA P-1000, from the USA to improve school safety against natural hazards by applying the guide to the infrastructure of Ecuadorian schools, focusing primarily on seismic risk. By considering the technical foundations of structuring and managing disasters in buildings for school use, society will be provided with a practical procedure to recognize those aspects that need immediate attention as part of proper risk management. Here, a variety of parameters are involved in the proposed methodology of the given guide from FEMA combined with the national construction standards and regulations. The characteristics of nearby geological faults and structural and nonstructural vulnerability levels, amongst others, were also considered to allow for a detailed evaluation and a subsequent seismic risk categorization. Finally, the global risk is determined for the studied institutions of Sangolquí in the Valley of Los Chillos, within the Interandean Depression in central Ecuador.