Modification of the terms of authorisation regarding the maximum inclusion level of Maxiban® G160 (narasin and nicarbazin) for chickens for fattening

Additives, Efsa Panel on; Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Dusemund, Birgit; Durjava, Mojca Kos; López‐Alonso, Marta; Puente, Secundino López; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Bories, Georges; Brantom, Paul; Gropp, Jürgen; Finizio, Antonio; Focks, Andreas; Teodorović, Ivana; Holczknecht, Orsolya; Tarrés‐Call, Jordi; Vettori, Maria Vittoria; Kouba, Maryline

doi:10.2903/j.efsa.2019.5786

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…235 in 2002, stipulating the MRL of nicarbazin in chicken and beef to be 200 μg/kg. 7,8 A large number of methods have been developed for the quantitative detection of imidocarb in various substrates. These include liquid chromatography−mass spectrometry (LC−MS/MS), 6,9,10 high-performance liquid chromatography−mass spectrometry, 11,12 and immunoassays.…”

Section: Introductionmentioning

confidence: 99%

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Sensitive Lateral Flow Immunoassay for the Residues of Imidocarb in Milk and Beef Samples

Wang

Guo

et al. 2021

ACS Omega

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Based on the successful derivation of a hapten, we prepared and optimized a murine monoclonal antibody against imidocarb, with an IC 50 of 2.22 ng/mL and a limit of detection (LOD) of 0.45 ng/mL. Cross-experiment results showed that the cross-over rate for 4,4′-dinitrocarbanilide was 18.12%, and the cross-reactivity with other analogues when using the ic ELISA was less than 0.1%. We used the developed ic-ELISA to detect the addition and recovery of imidocarb in milk and beef samples, and values were 86.0−93.5 and 84.5−101.2%, respectively. The preparation of an immunochromatographic test strip based on gold nanoparticles was used for the rapid identification of imidocarb in milk and beef samples. When assessed by the naked eye, the visual LOD for imidocarb in milk and beef samples was 5 and 10 ng/mL, and the cut-off values were 20 and 50 ng/mL, respectively. Because of its high sensitivity, specificity, and simplicity, the test strip can be used for on-site testing and rapid screening of imidocarb in food samples.

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Section: Introductionmentioning

confidence: 99%

“…The Ministry of Agriculture of China issued announcement no. 235 in 2002, stipulating the MRL of nicarbazin in chicken and beef to be 200 μg/kg. , …”

Section: Introductionmentioning

confidence: 99%

Sensitive Lateral Flow Immunoassay for the Residues of Imidocarb in Milk and Beef Samples

Wang

Guo

et al. 2021

ACS Omega

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Safety and efficacy of a feed additive consisting of lasalocid A sodium and nicarbazin (Nilablend™ 200G) for chickens for fattening (Zoetis Belgium SA)

Additives¹,

Bampidis²,

Azimonti³

et al. 2021

EFS2

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the coccidiostat Nilablend™ 200G containing lasalocid A sodium and nicarbazin. Nilablend™ 200G is not safe for chickens for fattening at the proposed maximum use level of 50 mg lasalocid A sodium + 50 mg nicarbazin/kg complete feed. Concurrent administration of Nilablend™ 200G (containing lasalocid A sodium) with tiamulin and certain other medicinal substances should be avoided. Lasalocid A sodium has antimicrobial activity against Gram‐positive bacterial species while many Enterobacteriaceae are naturally resistant. Induction of resistance and/or cross‐resistance was not observed in experimental conditions. No information on the interactions of nicarbazin with feed materials, other approved additives or medicinal products have been provided. No data were submitted on the microbiological safety of nicarbazin. The toxicological package for lasalocid A sodium and nicarbazin identified no observed adverse effect levels (NOAELs) that could be the basis for setting health‐based guidance values (e.g. an acceptable daily intake (ADI)). The Panel concluded that a concern for the genotoxicity of nicarbazin in Nilablend™ 200G cannot be excluded and that clarification on the mechanism of action of the test items would be needed. Therefore, the FEEDAP Panel is not in the position to establish an ADI for DNC on which to base the assessment of consumer safety. Nilablend™ 200G is considered toxic by inhalation, corrosive and irritant to eyes, slightly irritant to the skin but not a skin sensitiser. Inhalation exposure is considered a risk to persons handling the additive. The FEEDAP Panel cannot conclude on the safety of Nilablend™ 200G for the environment due to a possible risk for aquatic compartment (freshwater) for DNC. The efficacy of Nilablend® 200G was demonstrated.

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Revisiting the Economic Impacts of Eimeria and Its Control in European Intensive Broiler Systems With a Recursive Modeling Approach

et al. 2020

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Ionophore compounds active against Eimeria species are widely used in intensive broiler systems and have formed the backbone of coccidiosis control for almost 50 years. Producers, however, are under pressure to reduce ionophore use due to consumer concerns over antimicrobial usage in food animals, and antimicrobial resistance. Moreover, current vaccines against Eimeria are commonly considered to be less cost-effective in intensive broiler systems, especially in Europe where attenuated live vaccines are used. An economic assessment of the impact of Eimeria and the disease coccidiosis, including the cost implications of different efficacies of control, is therefore timely to provide evidence for industry and policy development. A mechanistic model of broiler production under varying infection and control states was used to construct a dataset from which system productivity can be measured. Coccidiosis impact increased rapidly as control efficacy decreased. In the total absence of control, median impact was found to maximize at between e2.55 and e2.97 in lost production per meter squared of broiler house over a 33 day growing period. Coccidiosis remains a major risk to intensive broiler systems and the model developed allows investigation of issues related to coccidiosis control, antimicrobial use and the development of antimicrobial resistance.

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Modification of the terms of authorisation regarding the maximum inclusion level of Maxiban® G160 (narasin and nicarbazin) for chickens for fattening

Cited by 3 publications

References 16 publications

Sensitive Lateral Flow Immunoassay for the Residues of Imidocarb in Milk and Beef Samples

Sensitive Lateral Flow Immunoassay for the Residues of Imidocarb in Milk and Beef Samples

Safety and efficacy of a feed additive consisting of lasalocid A sodium and nicarbazin (Nilablend™ 200G) for chickens for fattening (Zoetis Belgium SA)

Revisiting the Economic Impacts of Eimeria and Its Control in European Intensive Broiler Systems With a Recursive Modeling Approach

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