2021
DOI: 10.1002/jat.4269
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Modification of the toxic effects of methylmercury and thimerosal by testosterone and estradiol in SH‐SY5Y neuroblastoma cell line

Abstract: Short-chained alkyl mercury compounds accumulate in particularly in the brain. Exposure to these compounds is associated with various neurotoxic effects. Gender-based differences are observed in neurodevelopmental disorders, and testosterone and estradiol may alter the toxic effect of the compounds. The present study aimed to investigate the toxic effects of methylmercury and thimerosal on SH-SY5Y cells in high testosterone/low estradiol and high estradiol/low testosterone containing cellular environment and e… Show more

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Cited by 2 publications
(2 citation statements)
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“…In neural cells, both estradiol and progesterone influence neuronal survival 45 . Further, estradiol modified the toxic effects of chemicals (methylmercury and thimerosal) in neuroblastoma cell lines 46 . Estrogen can also have neuroprotective effects 47 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In neural cells, both estradiol and progesterone influence neuronal survival 45 . Further, estradiol modified the toxic effects of chemicals (methylmercury and thimerosal) in neuroblastoma cell lines 46 . Estrogen can also have neuroprotective effects 47 .…”
Section: Discussionmentioning
confidence: 99%
“…45 Further, estradiol modified the toxic effects of chemicals (methylmercury and thimerosal) in neuroblastoma cell lines. 46 Estrogen can also have neuroprotective effects. 47 Evidence has been mixed for a role of estrogens in NHL, 48,49 and a study in adults did not find associations between migraine and NHL.…”
Section: Discussionmentioning
confidence: 99%