Modified Calix[4]pyrrole Receptor:  Solution Thermodynamics of Anion Complexation and a Prelimenary Account on the Phosphate Extraction Ability of its Oligomer

Abstract

A modified calix[4]pyrrole, namely meso-tetramethyl-tetrakis-(4-hydroxyphenyl) calix[4]pyrrole, 1, has been synthesized and characterized. (1)H NMR investigations in various deuterated solvents seems to indicate that this receptor interacts with acetone-d(6). The solution thermodynamics of 1 in various solvents is reported. Complexation studies in CD(3)CN show that the NH and OH functionalities of 1 are the active sites of its interaction with the fluoride and the dihydrogen phosphate anions. The composition of the anion complexes was established through conductance measurements. In all cases, 1:1 complexes are formed. The thermodynamics of anion complexation in acetonitrile and N,N-dimethylformamide is discussed comparatively with previous reported data for the parent calix[4]pyrrole, 2, and these anions in these solvents. The medium effect on anion complexation is discussed in terms of the solvation properties of the reactants and the product in acetonitrile and N,N-dimethylformamide. An oligomeric material containing 1 as anchor group was synthesized and characterized by mass spectrometry. Preliminary studies have been performed to assess the extracting properties of this oligomer for the removal of phosphates from aqueous solutions. The effects of pH, temperature on the extraction of this anion salt from water, as well as the kinetics of the process (fast) were investigated.

Artificial Receptors for the Recognition of Phosphorylated Molecules

“…In general, this latter system gave rise to weaker anion interactions than receptor 783 . 815 The influence of the medium was also examined. While 806 displayed a preference for the fluoride anion in acetonitrile, in DMF dihydrogenphosphate was bound more strongly than F - (log K = 4.81 vs. 4.23, respectively).…”

Supramolecular anion recognition by tetrapyrrolic macrocycles

“…35 Muitos outros exemplos de CP meso substituídos têm sido reportados na literatura. [36][37][38][39][40][41] Atualmente tem-se apostado nesta abordagem sintética, por se mostrar mais versátil no desenvolvimento de novos sensores.…”

Selective binding and extraction of aqueous dihydrogen phosphate solutions via three-armed thiourea receptors

“…This leads to green and blue algal blooms with toxin-producing cyanobacteria strains that threaten aquatic life and drinking water safety 12 . Detection and extraction of phosphate from bio-and ecosystems, consequently is of critical importance [14][15][16][17][18][19] . Detection and extraction of phosphate from bio-and ecosystems, consequently is of critical importance [14][15][16][17][18][19] .…”