Modified chitosan nanogel-polymersomes for oral co-delivery of oxaliplatin and rapamycin for synergistic chemotherapy

Wande, Dickson Pius; Qiu, Yue; Chen, Shijie; Yao, Ling; Xu, Yanghui; Yao, Jianquan; Xiong, Hui

doi:10.1016/j.jddst.2022.103852

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…A number of experiments highlight the versatility of chitosan and its use in various anticancer applications, either as codelivery of oxaliplatin and rapamycin for synergistic chemotherapy [ 80 ] or by triggering other mechanisms, such as inhibition of the permeation-glycoprotein (P-gp), a protein with an important role in the management of cancer [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

α-Chitosan and β-Oligochitosan Mixtures-Based Formula for In Vitro Assessment of Melanocyte Cells Response

Schröder,

Gherghel,

Apetroaei

et al. 2024

IJMS

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Chitosan is a natural polymer with numerous biomedical applications. The cellular activity of chitosan has been studied in various types of cancer, including melanoma, and indicates that these molecules can open new perspectives on antiproliferative action and anticancer therapy. This study analyzes how different chitosan conformations, such as α-chitosan (CH) or β-oligochitosan (CO), with various degrees of deacetylation (DDA) and molar mass (MM), both in different concentrations and in CH–CO mixtures, influence the cellular processes of SK-MEL-28 melanocytes, to estimate the reactivity of these cells to the applied treatments. The in vitro evaluation was carried out, aiming at the cellular metabolism (MTT assay), cellular morphology, and chitinase-like glycoprotein YKL-40 expression. The in vitro effect of the CH–CO mixture application on melanocytes is obvious at low concentrations of α-chitosan/β-oligochitosan (1:2 ratio), with the cell’s response supporting the hypothesis that β-oligo-chitosan amplifies the effect. This oligochitosan mixture, favored by the β conformation and its small size, penetrates faster into the cells, being more reactive when interacting with some cellular components. Morphological effects expressed by the loss of cell adhesion and the depletion of YKL-40 synthesis are significant responses of melanocytes. β-oligochitosan (1.5 kDa) induces an extension of cytophysiological effects and limits the cell viability compared to α-chitosan (400–900 kDa). Statistical analysis using multivariate techniques showed differences between the CH samples and CH–CO mixtures.

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Section: Discussionmentioning

confidence: 99%

α-Chitosan and β-Oligochitosan Mixtures-Based Formula for In Vitro Assessment of Melanocyte Cells Response

Schröder,

Gherghel,

Apetroaei

et al. 2024

IJMS

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show abstract

“…It has been reported that febrile temperatures can influence the differentiation and pathogenicity of T helper 17 cells, suggesting that polymersomes responsive to exogenous stimuli accompanied by thermal effects generation could potentially enhance T cell activation. In addition to the subcutaneous administration, recently reported orally administrable polymersomes enable mucosal immunization through polymersomes. − The ideal candidate would be extremely stable in the acidic environment and respond to the basic environment of the intestinal tract to release both the antigen and adjuvants, thereby stimulating antigen-specific antitumor immunity. Other factors may affect the stimuli-responsive polymersomes application including the feasibility of the large production, the repeatability, the absolute biosafety in vivo in consideration of the inevitable organic solvent uses, etc .…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment

Wei,

Weng,

Wang

et al. 2024

Biomacromolecules

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The progression of cancer involves mutations in normal cells, leading to uncontrolled division and tissue destruction, highlighting the complexity of tumor microenvironments (TMEs). Immunotherapy has emerged as a transformative approach, yet the balance between efficacy and safety remains a challenge. Nanoparticles such as polymersomes offer the possibility to precisely target tumors, deliver drugs in a controlled way, effectively modulate the antitumor immunity, and notably reduce side effects. Herein, stimuli-responsive polymersomes, with capabilities for carrying multiple therapeutics, are highlighted for their potential in enhancing antitumor immunity through mechanisms like inducing immunogenic cell death and activating STING (stimulator of interferon genes), etc. The recent progress of utilizing stimuli-responsive polymersomes to reshape the TME is reviewed here. The advantages and limitations to applied stimuli-responsive polymersomes are outlined. Additionally, challenges and future prospects in leveraging polymersomes for cancer therapy are discussed, emphasizing the need for future research and clinical translation.

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“…Wande et al, in 2022, reported a nanogel-polymersomes drug delivery system based on modified chitosan, chitosan diacetate (CDA), methoxy-poly-(ethylene glycol)-b-poly (lactide) (MPP), and D-alpha-tocopheryl polyethylene glycol succinate (TPGS) with permeation-glycoprotein (P-gp) inhibition capability for enhancing the oral chemotherapy efficacy of erroneously soluble rapamycin and its synergistic chemotherapy with Oxaliplatin. The nanogel-polymersomes drug delivery system has tremendous potential for future cancer chemotherapy due to its surpassed Oxaliplatin, rapamycin, and Oxaliplatin and rapamycin mixtures (OR) in vitro cytotoxicity and in vivo antitumor chemotherapeutic efficacy [ 78 ]. In 2019, Mu and his team synthesized quercetin–chitosan conjugate (QT-CS) for oral delivery of doxorubicin (DOX) to improve its oral bioavailability by increasing its water solubility, opening tight junction and bypassing the P-glycoprotein (P-gp) [ 79 ].…”

Section: Applicability Of Chitosan-oriented Multifarious Deliverymentioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

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Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One of the most significant barriers that medications must overcome to exert a therapeutic effect is the impact of the first hepatic transit. Studies have shown that controlled-release systems using nanoparticles composed of biodegradable natural polymers significantly improve oral administration, which is why these materials have attracted significant attention. Chitosan possesses a wide variety of properties and functions in the pharmaceutical as well as healthcare industries. Drug encapsulation and transport within the body are two of its most important features. Moreover, chitosan can enhance drug efficacy by facilitating drug interaction with target cells. Based on its physicochemical properties, chitosan can potentially be synthesized into nanoparticles, and this review summarizes recent advances and applications of orally delivered chitosan nanoparticle interventions.

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Modified chitosan nanogel-polymersomes for oral co-delivery of oxaliplatin and rapamycin for synergistic chemotherapy

Cited by 6 publications

References 28 publications

α-Chitosan and β-Oligochitosan Mixtures-Based Formula for In Vitro Assessment of Melanocyte Cells Response

α-Chitosan and β-Oligochitosan Mixtures-Based Formula for In Vitro Assessment of Melanocyte Cells Response

Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment

Chitosan in Oral Drug Delivery Formulations: A Review

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