Modified Creatinine Index and the Risk of Bone Fracture in Patients Undergoing Hemodialysis: The Q-Cohort Study

Yamada, S.; Taniguchi, Masatomo; Tokumoto, Masanori; Yoshitomi, Ryota; Yoshida, Haruhiko; Tatsumoto, Narihito; Hirakata, Hideki; Fujimi, Satoshi; Kitazono, Takanari; Tsuruya, Kazuhiko

doi:10.1053/j.ajkd.2017.01.052

Cited by 50 publications

(60 citation statements)

References 43 publications

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“…One of the components of GNRI, serum albumin is extensively used as a traditional but controversial biochemical marker of nutritional status in HD patients because it is influenced by other factors such as over hydration, inflammation, protein loss, and catabolism during HD . In a cross‐sectional study, CI was significantly correlated with skeletal muscle mass measured by BIA . However, CI could not predict sarcopenia but was correlated with muscle strength in HD patients .…”

Section: Discussionmentioning

confidence: 92%

“…20 In a cross-sectional study, CI was significantly correlated with skeletal muscle mass measured by BIA. 16 However, CI could not predict sarcopenia but was correlated with muscle strength in HD patients. 13 Thus, creatinine represents an important marker of functional muscle mass but not the whole muscle mass.…”

Section: Discussionmentioning

confidence: 95%

“…17 Fat-free mass is also closely correlated with CI 16 and lower CI was also associated with increased risk for bone fractures in male and female HD patients. 16 CI is a more reliable indicator of long-term protein nutritional status and the trend decline of CI is also a powerful predictor of all-cause mortality. 18 Higher CI was associated with lower mortality and longer survival in men but not in women in subgroup analysis in a HD population.…”

Section: Discussionmentioning

confidence: 99%

“…Many methods have been used to measure muscle mass, such as dual energy X‐ray absorptiometry, bioelectrical impedance analysis (BIA), and anthropometric measurement. Recently, skeletal muscle mass measured by BIA was correlated with CI . CI is a simple formula based on patient demographics, single‐pool Kt/V of urea, and predialysis serum creatinine concentration developed and validated for HD patients .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, skeletal muscle mass measured by BIA was correlated with CI. 16 CI is a simple formula based on patient demographics, singlepool Kt/V of urea, and predialysis serum creatinine concentration developed and validated for HD patients. 4 CI derived from the simple creatinine kinetic modeling formula is a viable parameter than BMI to predict survival of HD patients.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Hwang

Cho

et al. 2018

Hemodialysis International

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Hwang

Cho

et al. 2018

Hemodialysis International

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Hypoxia‐inducible factor prolyl hydroxylase domain inhibitors may mitigate loss of skeletal muscle mass in haemodialysis patients

Hashimoto,

Mandai,

Shikuma

et al. 2024

JCSM Communications

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BackgroundChronic kidney disease patients particularly with renal anaemia hyporesponsive to erythropoiesis‐stimulating agents (ESAs) are at a greater risk of having skeletal muscle mass (SMM) loss. Hypoxia‐inducible factor prolyl hydroxylase domain inhibitor (HIF‐PHI), a novel therapeutic agent for renal anaemia, potentially promotes angiogenesis, muscle repair, and homeostasis. However, effects of HIF‐PHIs on SMM remain unknown.MethodsThis retrospective observational cohort study enrolled 292 Japanese adults receiving maintenance haemodialysis at our dialysis centre. The dataset included 11 patients who received daprodustat for 6 months or longer during 1 December 2020 through 30 June 2022. From the previously published pooled cohort, we enrolled 281 participants from 1 August 2018 to 31 July 2019 prior to the approval of HIF‐PHIs for renal anaemia. SMM was assessed using modified creatinine index (mg/kg/day) calculated by age, sex, serum creatinine, and single‐pool Kt/V. Annual changes of SMM [ΔSMM (%)] were analysed with the least squares regression model and mixed‐effects model during 6‐ to 12‐month follow‐up period.ResultsThe median age of the participants was 63 years [interquartile range (IQR), 54–71 years], and 33% were female. The median ΔSMM levels (IQR) in the least squares regression model were 4.0% (−1.7% to 9.3%) in the HIF‐PHI group, 0.20% (−2.1% to 2.1%) in the no ESA group, and −0.94% (−3.0% to 1.3%) in the high ESA group using darbepoetin equivalent to 20 μg or more per week. Those in the mixed‐effects model were −1.7% (−1.2% to 3.8%), 0.09% (−1.4% to 1.3%), and −0.74% (−2.0% to 0.8%), respectively. The multivariable linear regression models revealed that HIF‐PHI use was associated with greater ΔSMM compared with the high ESA group [coefficient, 3.737; 95% confidence interval (CI), 1.216–6.258 in the least squares regression model or coefficient, 1.635; 95% CI, 0.068–3.201 in the mixed‐effects model, respectively].ConclusionsHIF‐PHI use led to greater ΔSMM in maintenance haemodialysis patients. HIF‐PHIs may minimize loss of SMM in patients with end‐stage kidney disease and renal anaemia.

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Associations Between Surrogates of Skeletal Muscle Mass and History of Bone Fracture in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry (FKR) Study

et al. 2021

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Modified Creatinine Index and the Risk of Bone Fracture in Patients Undergoing Hemodialysis: The Q-Cohort Study

Cited by 50 publications

References 43 publications

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Hypoxia‐inducible factor prolyl hydroxylase domain inhibitors may mitigate loss of skeletal muscle mass in haemodialysis patients

Associations Between Surrogates of Skeletal Muscle Mass and History of Bone Fracture in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry (FKR) Study

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