“…Shortly after the identification and isolation of the virus responsible for the acquired immune deficiency syndrome (AIDS) (subsequently named the human immunodeficiency virus, HIV), several groups, following a suggestion of De Clercq (1986), demonstrated that heparin and other polysulfates are potent and selective inhibitors of HIV-1 replication in cell culture (Ito et el., 1987(Ito et el., , 1991suya et el., 1988;Mizumoto et ei., 1988;Yoshida et al, 1988;Hirabayashi et el., 1989;Jurkiewicz et el., 1989;Sugawara et al, 1989;Tochikura et al, 1989;Anand et el., 1990a,b;Kaneko et al, 1990;Montefiori et al, 1990;Weiler et al, 1990;Schols et sl., 1990aSchols et sl., , 1991Von Briesen et al, 1990;Aoki et al, 1991;Bagasra et al, 1988Bagasra et al, , 1991Sosa et al, 1991;Handa et al, 1991;Hatanaka et al, 1991;McClure et al, 1991;Moriya et al, 1991Moriya et al, , 1993Otake et al, 1991Otake et al, , 1994Witvrouw et al, 1991Witvrouw et al, , 1992Witvrouw et al, , 1994Mizuno et al, 1992;Uryu et al, 1992;Barzu et al, 1993;Beutler et al, 1993;Damonte et el., 1994). Several polysulfates were also found to be active against a wide variety of enveloped viruses (Baba et el., 1988c;De Clercq, 1990, 1993;Andrei et el., 1991;Schols et al...…”