Modified Fish Gelatin as an Alternative to Mammalian Gelatin in Modern Food Technologies

Derkach, Svetlana R.; Voron’ko, Nikolay G.; Kuchina, Yuliya A.; Kolotova, Daria S.

doi:10.3390/polym12123051

Cited by 85 publications

(47 citation statements)

References 69 publications

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“…Collagen consists of a triple helix of peptides of around 100 kDa (α-chains), assembled in the extracellular matrix into aggregates forming fibrils [ 1 ]. Disruption of the triple helix structure turns very insoluble collagen into soluble gelatin, a more tractable material that has found many applications in the food, pharmaceutical, and biomedical industries [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Sources of commercial gelatin comprise mostly pig and cattle bones, skins, and hides, but growing interest exists in fish gelatin. On the one hand, as a substitute of terrestrial animals for cultural reasons, but also as properties of fish gelatins, different to those of mammalian counterparts, may better suit particular applications [ 2 , 3 ]. As a result, many works have dealt with the extraction and properties of gelatin from a wide range of fish species [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Gelatin and Hydrolysates from Valorization of Farmed Salmon Skin By-Products

et al. 2021

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Salmon processing commonly involves the skinning of fish, generating by-products that need to be handled. Such skin residues may represent valuable raw materials from a valorization perspective, mainly due to their collagen content. With this approach, we propose in the present work the extraction of gelatin from farmed salmon and further valorization of the remaining residue through hydrolysis. Use of different chemical treatments prior to thermal extraction of gelatin results in a consistent yield of around 5%, but considerable differences in rheological properties. As expected from a cold-water species, salmon gelatin produces rather weak gels, ranging from 0 to 98 g Bloom. Nevertheless, the best performing gelatins show considerable structural integrity, assessed by gel permeation chromatography with light scattering detection for the first time on salmon gelatin. Finally, proteolysis of skin residues with Alcalase for 4 h maximizes digestibility and antihypertensive activity of the resulting hydrolysates, accompanied by the sharpest reduction in molecular weight and higher content of essential amino acids. These results indicate the possibility of tuning salmon gelatin properties through changes in chemical treatment conditions, and completing the valorization cycle through production of bioactive and nutritious hydrolysates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Gelatin and Hydrolysates from Valorization of Farmed Salmon Skin By-Products

et al. 2021

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“…The main sources of gelatin are bovine skin, bovine hides, and cattle and pork bones, whereas fish and poultry gelatins are used to a limited extent [ 1 ]. Gelatin from cold-water fish contains a lower percentage of proline and hydroxyproline which are involved in the formation of collagen-like triple helices and therefore has inferior gelation properties in comparison with mammalian gelatins [ 1 , 2 ]. Being biocompatible (included in FDA’s GRAS list), low-immunogenic, cheap, and commonly available biopolymer gelatin gains popularity in biomedicine, biotechnology, and food science [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Modified Desolvation Method Enables Simple One-Step Synthesis of Gelatin Nanoparticles from Different Gelatin Types with Any Bloom Values

et al. 2021

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Gelatin nanoparticles found numerous applications in drug delivery, bioimaging, immunotherapy, and vaccine development as well as in biotechnology and food science. Synthesis of gelatin nanoparticles is usually made by a two-step desolvation method, which, despite providing stable and homogeneous nanoparticles, has many limitations, namely complex procedure, low yields, and poor reproducibility of the first desolvation step. Herein, we present a modified one-step desolvation method, which enables the quick, simple, and reproducible synthesis of gelatin nanoparticles. Using the proposed method one can prepare gelatin nanoparticles from any type of gelatin with any bloom number, even with the lowest ones, which remains unattainable for the traditional two-step technique. The method relies on quick one-time addition of poor solvent (preferably isopropyl alcohol) to gelatin solution in the absence of stirring. We applied the modified desolvation method to synthesize nanoparticles from porcine, bovine, and fish gelatin with bloom values from 62 to 225 on the hundreds-of-milligram scale. Synthesized nanoparticles had average diameters between 130 and 190 nm and narrow size distribution. Yields of synthesis were 62–82% and can be further increased. Gelatin nanoparticles have good colloidal stability and withstand autoclaving. Moreover, they were non-toxic to human immune cells.

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“…[35] Mammalian-derived gelatin is another example of a thermoresponsive naturally derived polymer that can experience reversible sol-gel transitions upon temperature variations (at temperatures above 30 °C, gelatin is in a soluble state, while at temperatures below 25 °C gelatin is in a gel state). [61] Importantly, these temperature ranges are highly dependent on gelatin origin, with fish skin gelatin presenting an entirely different temperature profile (for example, 4-8 °C gelling and 16-18 °C melting [90] ), which is also dependent on the type of fish living areas (i.e., cold or warm water).…”

Section: Stimuli Classificationmentioning

confidence: 99%

Natural Origin Biomaterials for 4D Bioprinting Tissue‐Like Constructs

Costa

Correia

et al. 2021

Adv Materials Technologies

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Leveraging 4D biofabrication for engineering biomimetic living constructs is rapidly emerging as a valuable strategy for recapitulating native tissue dynamics, via on‐demand stimuli, or in a naturally evolving mode. Carefully selecting smart materials with suitable responsiveness and cell‐supporting functionalities is crucial to take full operational advantage of this next‐generation technology. Recent endeavors combining naturally available polymers or hybrid smart materials improve the potential to manufacture volumetrically defined, cell‐rich constructs that may display stimuli–responsive properties, shape memory/shape morphing features, and/or dynamic motion in time. In this review, natural origin biomaterials and the stimuli that can be exploited for granting dynamic morphological features and functionalities post‐printing are highlighted. A broad overview of recent reports focusing on 4D‐bioprinted constructs for tissue engineering and regenerative medicine is also provided and critically discussed in light of current challenges, as well as foreseeable advances. It is envisioned that upon assurance of key regulatory demands, such technology will become translatable to numerous biomedical applications that require fabrication of constructs with dynamic functionality.

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Modified Fish Gelatin as an Alternative to Mammalian Gelatin in Modern Food Technologies

Cited by 85 publications

References 69 publications

Characterization of Gelatin and Hydrolysates from Valorization of Farmed Salmon Skin By-Products

Characterization of Gelatin and Hydrolysates from Valorization of Farmed Salmon Skin By-Products

Modified Desolvation Method Enables Simple One-Step Synthesis of Gelatin Nanoparticles from Different Gelatin Types with Any Bloom Values

Natural Origin Biomaterials for 4D Bioprinting Tissue‐Like Constructs

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