Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug

Soe, May Thu; Limpongsa, Ekapol; Jaipakdee, Napaphak

doi:10.1016/j.carbpol.2020.116556

Cited by 39 publications

(17 citation statements)

References 37 publications

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“…The surface characteristics of freestanding films can be fine‐tuned by different post‐treatment techniques. Owing to its outstanding mechanical and biological properties, chitosan nanocomposite films have already been used in various biomedical applications including wound dressing patches, 48–51 drug delivery, 52,53 implant coatings, 54–56 and as scaffolds 57,58 . Various nanoparticles such as nanoclay, 59 graphene, 60 silver, 61 cellulose whisker, 62 and titania 63 have been used for the preparation of chitosan nanocomposites films for such applications.…”

Section: Chitosan‐based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary physico-chemical characteristics and properties. While a primary use of chitosan has been in horticultural and agricultural applications for plant defense and to increase crop yield, recent research reports display various new utilizations in the field of advanced biomedical devices, targeted drug delivery, and as bioimaging sensors. Chitosan possesses multiple characteristics such as antimicrobial properties, stimuli-responsiveness, tunable mechanical strength, biocompatibility, biodegradability, and water-solubility. Further, chitosan can be processed into nanoparticles, nano-vehicles, nanocapsules, scaffolds, fiber meshes, and 3D printed scaffolds for a variety of applications. In recent times, nanoparticles incorporated in chitosan matrices have been identified to show superior biological activity, as cells tend to proliferate/differentiate faster when they interact with nanocomposites rather than bulk or micron size substrates/scaffolds. The present article intents to cover chitosan-based nanocomposites used for regenerative medicine, wound dressings, drug delivery, and biosensing applications.

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Section: Chitosan‐based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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“…Penggunaan pati maupun kitosan sebagai eksipien farmasi telah banyak digunakan tetapi untuk memaksimalkan hasil atau fungsional dari kedua material tersebut pati dan kitosan sering digabungkan menjadi satu material baru yang dimana kekurangan dan kelebihan dari kedua material dapat di tutupi satu sama lainnya. Pencampuran pati dan kitosan merupakan salah satu cara untuk meningkatkan sifat mekanik, penghalangan uap air, sifat antimikroba, meningkatkan biodegradabilitas pada film kitosan 13 serta dapat memberikan sifat unggul pada sediaan 14 . Penggabungan dari penambahan material tersebut biasa disebut juga sebagai komposit 15 .…”

Section: Gambar 2 Struktur Kimia Kitosanunclassified

“…Komposit pati-kitosan telah banyak digunakan dalam sistem penghantaran obat yang diringkas dalam dalam Tabel 1. Sistem penghantaran yang dilaporkan meliputi bentuk film 3,7,14,22,25,30,31 , nanopartikel 8,13,32 , tablet 33,34,35,36 , dan gel atau hidrogel 34,35,12,39 .…”

Section: Hasil Dan Pembahasanunclassified

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Review Komposit Pati–Kitosan: Perannya dalam Berbagai Sistem Penghantaran Obat

2022

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AbstrakPati adalah polisakarida yang berasal dari alam yang banyak terdapat secara luas dalam biji, buah, akar, dan batang. Pati sering digunakan sebagai salah satu zat tambahan dalam sediaan farmasi karena pati memiliki sifat polimer hidrofilik yang dapat dengan mudah diubah menjadi berbagai bentuk karena tidak beracun, bersifat biodegradable, inert, biokompatibilitas, mudah ditemukan dan harganya yang relatif murah. Dalam dunia farmasi untuk mengoptimalkan fungsi dari pati biasanya pati sering digabungkan dengan kitosan sebagai komposit, karena penggabungan tersebut dapat meningkatkan kelarutan, mengurangi toksisitas dalam tubuh, meningkatkan aktivitas farmakologi, meningkatkan stabilitas, meningkatkan biodegradabilitas dan memberikan sifat unggul pada sediaan tersebut. Penulisan review artikel ini bertujuan untuk mengumpulkan informasi tentang penggunaan komposit pati-kitosan sebagai eksipien dalam berbagai sistem penghantaran obat. Penulisan karya tulis ilmiah ini menggunakan review pustaka. Penelusuran pustaka dilakukan menggunakan database Google, Google Schoolar, Science Direct, Pubmed dan MDPI. Sumber pustaka yang digunakan yaitu 10 tahun terakhir dengan rentang tahun 2011-2021 dengan kriteria inkulsi yaitu komposit pati kitosan yang memiliki peran dalam sistem penghantaran obat; kriteria eksklusi yaitu pati dan kitosan yang tidak relevan. Berdasarkan review artikel yang dilakukan didapatkan hasil dari pati dan kitosan yang dapat digunakan untuk sistem penghantaran obat dalam berbagai sediaan seperti film, nanopartikel, tablet dan juga gel. adanya peningkatan manfaat pada komposit pati kitosan dalam sediaan film, nanopartikel, tablet dan juga gel. Komposit ini dapat memberikan material baru yang lebih optimal dibandingkan dengan penggunaan tunggal.

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“…HPMC represents one of the most widely used mucoadhesive polymers for buccal drug delivery owed to its hydrogel forming ability, which was ideal for producing a sustained drug release profile [42,43]. Starches, on the other hand, have only been recently investigated for buccal drug delivery, despite their well-established film-forming ability [44][45][46]. Starches, nevertheless, have many applications in pharmaceutical formulations, for example, as fillers/binders/disintegrants in oral tablets [47].…”

Section: Introductionmentioning

confidence: 99%

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

Lim

Hadinoto

2021

IJMS

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Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR–chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films’ characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.

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Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug

Cited by 39 publications

References 37 publications

Chitosan‐based nanocomposites for medical applications

Chitosan‐based nanocomposites for medical applications

Review Komposit Pati–Kitosan: Perannya dalam Berbagai Sistem Penghantaran Obat

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

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