Modified Lignin with Anionic Surfactant and Its Application in Controlled Release of Avermectin

Li, Yuanyuan; Yang, Dongjie; Lu, Shuo; Lao, Sulin; Qiu, Xueqing

doi:10.1021/acs.jafc.8b00393

Cited by 74 publications

(45 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They loaded the particles with hydrophobic insecticide Avermectine during the precipitation step and investigated both drug release and UV protection capability of the microparticles. The release into 1:1 methanol:water was somewhat sustained with about 80% of the drug being released in 72 h. The anti-photolysis properties of the lignin proved to be very good, after 96 h of UV irradiation 85% of the drug was still preserved in the spheres [ 75 ]. The same group also reported lignin droplets in a Pickering emulsion coated with polyuria for a sustained Avermectine release.…”

Section: Lignin-derived Biomaterials For Drug Encapsulation/releasmentioning

confidence: 99%

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

et al. 2018

View full text Add to dashboard Cite

Renewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on its resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as a renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, the literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is placed on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies.

show abstract

Section: Lignin-derived Biomaterials For Drug Encapsulation/releasmentioning

confidence: 99%

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Gregorova et al studied the encapsulation of lignin nanoparticles in polyethylene films (Björkman lignin from beech wood flour) [13]. In other studies, the delivery of Resveratrol ® [14], the controlled release of Avermectin ® [15], lignin-polyurea microcapsules with anti-photolysis and sustained-release performances [16], montmorillonite-lignin hybrid hydrogel as super-sorbent for dye removal from wastewater [17], cellulose-lignin hydrogels and their controlled release of polyphenols [18], lignin-stimulated protection of polypropylene films Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…The best results in terms of an increase in OH content and use for PF resins was the sample demethylated with Na 2 SO 3 . Other authors used Na 2 SO 3 for demethylation performed under high-pressure reactors [39] or under reflux [15,40]. Podschun et al chose a different approach in which organosolv lignin was demethylated under microwave radiation [41].…”

mentioning

confidence: 99%

Antimicrobial Activity of Lignin-Derived Polyurethane Coatings Prepared from Unmodified and Demethylated Lignins

et al. 2019

View full text Add to dashboard Cite

Due to global ecological and economic challenges that have been correlated to the transition from fossil-based to renewable resources, fundamental studies are being performed worldwide to replace fossil fuel raw materials in plastic production. One aspect of current research is the development of lignin-derived polyols to substitute expensive fossil-based polyol components for polyurethane and polyester production. This article describes the synthesis of bioactive lignin-based polyurethane coatings using unmodified and demethylated Kraft lignins. Demethylation was performed to enhance the reaction selectivity toward polyurethane formation. The antimicrobial activity was tested according to a slightly modified standard test (JIS Z 2801(JIS Z :2010. Besides effects caused by the lignins themselves, triphenylmethane derivatives (brilliant green and crystal violet) were used as additional antimicrobial substances. Results showed increased antimicrobial capacity against Staphylococcus aureus. Furthermore, the coating color could be varied from dark brown to green and blue, respectively.Coatings 2019, 9, 494 2 of 16 and DNA in cells of mice against oxidation damage [19] have been tested. Gao [20] and Bshena [21] studied the antimicrobial activity of various textiles, using lignin incorporated into polyethylene films and applied in the finishing processes. For textiles, there are special requirements such as non-toxicity to the consumer, namely cytotoxicity, allergy or irritation and sensitization. In other recent studies, lignosulfonic acid is reported to exhibit broad-spectrum anti-HIV (human immunodeficiency virus) and anti-HSV (herpes simplex virus) properties [22,23]. Thus, Qiu investigated the anti-HIV-1 activity-potential of lignosulfonates as a microbicide to prevent HIV-1 sexual transmission [23]. Another recently reported study revealed that the antimicrobial capacity of lignin correlates with the phenolic components, specifically the side chain structure and the nature of further functional groups [24]. Typically, the presence of a double bond in α, β positions of the side chain and a methyl group in the γ position grants the phenolic fragments with the most potency against microorganisms. However, none of the hitherto published studies included the investigation of the antibacterial activity of lignin when included in polymeric matrices.Unmodified lignin is widely studied as a component for polymer production with a focus on phenol-formaldehyde resins and polyurethanes (PUs) [25], where lignin is used as polyol substitute due to the high amount of hydroxyl groups resulting in high crosslinking densities and variable mechanical properties [26][27][28]. In previous studies, lignin-derived polyurethane coatings have been prepared using Kraft lignin isolated at room temperature from aqueous media (black liquor) at different pH values [29]. In addition, their antioxidative activity has been investigated using the Folin-Ciocalteu (FC) assay [30]. Although lignin contains many functionalities, they are often diff...

show abstract

“…The preparation of novel materials from lignin/lignin‐derived products can improve theeconomics of polymer composite materials as well as possibly address the problem of its waste disposal . The applications include the production of epoxy, polivinilalcohol, polydimethylsiloxane, polypropylene, polyethylene, controlled drug release, ion removal, hydrogels, bitumen, refiner(carbon cracker), cement additives, biofuel, high‐grade lignin, mixtures of benzene, toluene, and xylene (BTX),activated carbon, phenolic resins, carbon fibers, and vanillin…”

Section: Introductionmentioning

confidence: 99%

Hydroxymethylation of technical lignins from South American sources with potential use in phenolic resins

Taverna

Felissia

Área

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

This work investigates the valorization of sodium lignosulfonate, kraft, and organosolv lignins from South America. A detailed characterization of the lignins and their chemical modification by hydroxymethylation through its reaction with formaldehyde were performed. The characterization included measurements of moisture, ash, carbohydrate contents, elemental and thermogravimetric analysis, and functional groups, molar mass distributions by Fourier transform infrared spectroscopy, and size exclusion chromatography, respectively. Also, reactive aromatic hydrogens ( H Ar ) were quantified by the measurement of phenolic hydroxyl groups (P-OH) content by UV-Vis spectroscopy. The different initial formaldehyde/lignin weight ratios (0.07, 1.47), temperatures (40, 50, and 70 C), and pHs (9, 11); and the following of hydroxymethylation reactions by UV-Vis spectroscopy were investigated. All lignins resulted attractive for the use as replacement of phenol in phenolic resins, but sodium lignosulfonate was the most appropriate due to its water solubility.

show abstract

Modified Lignin with Anionic Surfactant and Its Application in Controlled Release of Avermectin

Cited by 74 publications

References 41 publications

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

Antimicrobial Activity of Lignin-Derived Polyurethane Coatings Prepared from Unmodified and Demethylated Lignins

Hydroxymethylation of technical lignins from South American sources with potential use in phenolic resins

Contact Info

Product

Resources

About