This paper aims to achieve minimum life-cycle cost, by applying a seismic design optimization of the steel frames with semiactive magnetorheological (MR) dampers. The total life-cycle cost, which includes the initial constructional and expected damage costs, is an adequate goal to satisfy both employer and users. For optimal performance of the dampers, two fuzzy control systems are suggested, each having two different inputs. Results of numerical analysis for an 11-story steel structure show that using MR dampers decreases the interstory drift ratios to a permissible limit. It also reduces life-cycle cost when the design is optimum and when the dampers are evenly distributed by 23% and 14%, respectively. In the case where the objective function was to minimize the total life-cycle cost, the expected injury and fatality, as the most crucial financial parameters, had the highest decrease rate. There was also a 17% drop in comparison to the state that the dampers are evenly distributed. The fuzzy control with drift and velocity as inputs had better performance in minimizing the total life-cycle cost than the other fuzzy control, which used acceleration instead of velocity.