Modified mRNA-Based Vaccines Against Coronavirus Disease 2019

Abstract

The pandemic of coronavirus disease 2019 (COVID-19) continuously causes deaths worldwide, representing a considerable challenge to health care and economic systems with a new precedent in human history. Many therapeutic medicines primarily focused on preventing severe organ damage and complications, which can be fatal in some confirmed cases. The synthesized modified mRNA (modRNA) represents a nonviral, integration-free, zero-footprint, efficient, and safe strategy for vaccine discovery. modRNA-based technology has facilitated the rapid development of the first COVID-19 vaccines due to its cost- and time-saving properties, thus initiating a new era of prophylactic vaccines against infectious diseases. Recently, COVID-19 modRNA vaccines were approved, and a large-scale vaccination campaign began worldwide. To date, results suggest that the modRNA vaccines are highly effective against virus infection, which causes COVID-19. Although short-term studies have reported that their safety is acceptable, long-term safety and protective immunity remain unclear. In this review, we describe two major approved modRNA vaccines and discuss their potential myocarditis complications.

Potential Application of Modified mRNA in Cardiac Regeneration

“…The modRNA utilized in this treatment contained ARCA, poly-A tail, m5C, and ΨU modifications. Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has invaded the world, which has promoted the generation of modRNA-based vaccines such as Moderna 1273 with N1-methyl-pseudouridine modification and Pfizer/BNT 162b2 with proline mutation against the COVID-19 pandemic 39 . In addition, interleukin (IL)-10 modRNA has been used to directly produce the anti-inflammatory IL-10 protein in vivo, resulting in prolonged survival of facial allografts through the induction of mixed chimerism 40 .…”