Modified-release capsules containing sodium riboflavin 5′-phosphate

Abstract

A new solid dosage form was developed which can enhance the bioavailability of riboflavin. RRSBW distribution and the Chapman-Richards growth function were used to fit the dissolution profiles. Statistical analysis indicated that the best products were described by the Chapman-Richards equation. The results were utilized to create a theoretical model suitable for prediction of the optimum film thickness that ensures the required release of riboflavin.

Antimicrobial properties of poly (vinyl alcohol) films with zeolitic imidazolate framework (ZIF‐8) nanoparticles for food packaging

“…The release rate (RR) of TC from the films was calculated as follows: $$$$\begin{equation}{\rm{RR}}\;\left( \% \right) = \;\frac{{{W_R}}}{{{W_T}}} \times 100,\end{equation}$$$$where W R (µL/g) is the amount of TC released from the films, and W T (µL/g) is the total TC in the films (Lin et al., 2019). The effect of temperature on RR was described by the Chapman Richards model: $$$$\begin{equation}{\rm{RR}}\; = \;a{\left[ {1 - {\rm{exp}}\left( { - kt} \right)} \right]^c},\end{equation}$$$$where RR is the release rate of TC dissolved/released (percentage) as a function of time, t is time (h), a is the amount of TC released during the burst phase (percentage), k is the release rate constant (1/h), and c describes the shape of the dissolution curve progression (if c = 1, the shape of the curve corresponds exactly to the shape of an exponential profile) (Buchholcz et al., 2014; Vasconcelos et al., 2012).…”

“…where RR is the release rate of TC dissolved/released (percentage) as a function of time, t is time (h), a is the amount of TC released during the burst phase (percentage), k is the release rate constant (1/h), and c describes the shape of the dissolution curve progression (if c = 1, the shape of the curve corresponds exactly to the shape of an exponential profile) (Buchholcz et al, 2014;Vasconcelos et al, 2012).…”

Photodynamic Inactivation of Foodborne Bacteria: Screening of 32 Potential Photosensitizers

“…These PS candidates were selected based on multiple characteristics, such as the formation of a uniform solution in their respective solvents, stability of the solution formed (i.e., no precipitation during storage), and ability to reduce the biofilms by at least 3 log 10 CFU/peg-or, where the dark VCs yielded less than 3 log 10 CFU/peg, a "max kill" (corresponding to no colonies obtained from the treated biofilms). Riboflavin-5 ′ -phosphate and riboflavin are chemically almost identical, with the sole difference being a phosphate group to enhance water solubility [38,39].…”

Recent progress in preparation and agricultural application of microcapsules

“…The total riboflavin (100%) microcapsule dissolved in artificial gastric and intestinal fluid during 60 min and the predicted optimum film thickness is 112.1 μm, which calculated by the Chapman-Richards equation. After release from the microcapsule core, riboflavin will be easily absorbed or restored in upper gastrointestinal tracts and converted to flavin mononucleotide by a specific transport mechanism involving the phosphorylation of vitamins(Buchholcz et al, 2014). Moreover, as the most important nonprotein nitrogen source in ruminants, urea has a vital function in supplementing the protein of ruminants.…”