Modified Silica Matrices for Controlled Release of Cephalexin

Abstract

SBA-15 type ordered silicas possessing amino groups attached onto their surfaces were prepared by using two different functionalization methodologies. These matrices were used for the cephalexin adsorption from aqueous solution and further kinetic study of its release into physiological solution. The materials were characterized by nitrogen adsorption/ desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV-visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded amino groups and their location, which in turn is determined by the functionalization procedure used. It was concluded that amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.

A novel zwitterionic bioceramic with dual antibacterial capability

“…Loading assays were carried out by soaking powdered samples in water (pH $ 6). 52 Elemental chemical analyses were used to quantify the amount of CPX loaded into the different mesoporous samples. The results are shown in Table 4, 11.2 and 12.7 mg g À1 being the amounts of CPX loaded for SBA-15 and SBA-Zwitter, respectively.…”

Influence of particle size on the adsorption and release of cephalexin encapsulated in mesoporous silica SBA-15

“…In previous work we demonstrated that cephalexin could successfully be loaded on SBA-15 mesoporous silica [16][17][18].…”

The role of SBA-15 in drug delivery

“…In contrast, the fastest release was observed for CPX/SBA-15-Pr-SO 3 H since there are not interactions occurred between the CPX molecules and the sulfonic acids on the surface, despite the presence of an amino group in the CPX molecule 78. In another publication, it was demonstrated that, post-functionalization SBA-15-Pr-NH 2 could enhance the long-term CPX delivery in comparison with the co-condensation procedure 79. …”