Modified Solenoid Coil That Efficiently Produces High Amplitude AC Magnetic Fields With Enhanced Uniformity for Biomedical Applications

Bordelon, David E.; Goldstein, Robert C.; Nemkov, Valentin; Kumar, Abhishek; Jackowski, John; DeWeese, Theodore L.; Ivkov, Robert

doi:10.1109/tmag.2011.2162527

Cited by 74 publications

(63 citation statements)

References 22 publications

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“…The AMF system has been previously described, 6,7 and it comprises 4 main components: a power supply, an external impedance matching network, a modified solenoid coil as the inductor, and a closed-circulating water cooling system. The power supply is an 80-kW induction heating system manufactured by PPECO that provides an alternating current to a resonant circuit with variable frequency between 135 kHz and 440 kHz.…”

Section: The Amf Systemmentioning

confidence: 99%

“…Detailed descriptions of the design, build, and characterization of the modified solenoid coil have been published previously. 6,7,33 Briefly, when combined the system is capable of producing a homogeneous flux density AC magnetic field (at 150 kHz) in a cylindrical volume having a 5-cm diameter with a > 6-cm length, for peak-topeak amplitudes between 4 kA/m and 95 kA/m. The field amplitude can be dynamically controlled by adjusting the power supply output voltage.…”

Section: The Amf Systemmentioning

confidence: 99%

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Characterization of intratumor magnetic nanoparticle distribution and heating in a rat model of metastatic spine disease

Zadnik¹,

Molina²,

Sarabia-Estrada³

et al. 2014

SPI

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Object The goal of this study was to optimize local delivery of magnetic nanoparticles in a rat model of metastatic breast cancer in the spine for tumor hyperthermia while minimizing systemic exposure. Methods A syngeneic mammary adenocarcinoma was implanted into the L-6 vertebral body of 69 female Fischer rats. Suspensions of 100-nm starch-coated iron oxide magnetic nanoparticles (micromod Partikeltechnologie GmbH) were injected into tumors 9 or 13 days after implantation. For nanoparticle distribution studies, tissues were harvested from a cohort of 36 rats, and inductively coupled plasma mass spectrometry and histopathological studies with Prussian blue staining were used to analyze the samples. Intratumor heating was tested in 4 anesthetized animals with a 20-minute exposure to an alternating magnetic field (AMF) at a frequency of 150 kHz and an amplitude of 48 kA/m or 63.3 kA/m. Intratumor and rectal temperatures were measured, and functional assessments of AMF-exposed animals and histopathological studies of heated tumor samples were examined. Rectal temperatures alone were tested in a cohort of 29 rats during AMF exposure with or without nanoparticle administration. Animal studies were completed in accordance with the protocols of the University Animal Care and Use Committee. Results Nanoparticles remained within the tumor mass within 3 hours of injection and migrated into the bone at 6, 12, and 24 hours. Subarachnoid accumulation of nanoparticles was noted at 48 hours. No evidence of lymphoreticular nanoparticle exposure was found on histological investigation or via inductively coupled plasma mass spectrometry. The mean intratumor temperatures were 43.2°C and 40.6°C on exposure to 63.3 kA/m and 48 kA/m, respectively, with histological evidence of necrosis. All animals were ambulatory at 24 hours after treatment with no evidence of neurological dysfunction. Conclusions Locally delivered magnetic nanoparticles activated by an AMF can generate hyperthermia in spinal tumors without accumulating in the lymphoreticular system and without damaging the spinal cord, thereby limiting neurological dysfunction and minimizing systemic exposure. Magnetic nanoparticle hyperthermia may be a viable option for palliative therapy of spinal tumors.

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Section: The Amf Systemmentioning

confidence: 99%

Section: The Amf Systemmentioning

confidence: 99%

Characterization of intratumor magnetic nanoparticle distribution and heating in a rat model of metastatic spine disease

Zadnik¹,

Molina²,

Sarabia-Estrada³

et al. 2014

SPI

Self Cite

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“…Typical applications include optical magentometery [5], spectroscopy [6] and biomedical applications [7][8][9]. Air-core solenoid coils are preferred choice owing to high peak amplitude field and an internal cavity for holding the test element to be magnetically permeated.…”

Section: Introductionmentioning

confidence: 99%

Design and Analysis of Multilayer Solenoid Coil for Faraday Modulator

et al. 2017

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Abstract.A well-designed polarimeter is integral to the realization of the highly sensitive atomic magnetometer. Amongst various detection schemes, optical polarimetry based on Faraday modulator is most commonly used owing to its angular sensitivity at low-frequency range. The multilayered solenoid coil is the key component of Faraday effect based optical detection system. This paper primarily deals with design and analysis of multilayered coil of Faraday modulator. All deterministic parameters that affect the optimum design have been identified and analyzed. Mathematical expressions have been obtained for axial field homogeneity; modulation depth and power dissipation manifesting direct dependence on coil geometry. The design parameters of the coil are optimized with respect to axial magnetic field homogeneity over region of interest and reduced power losses with suitable geometric construction. The influence of different geometrical and electromagnetic parameters on optimum design has been highlighted and guidelines for design procedure are given. Theoretical results have been compared with simulation and experimental results. The mathematical formulation could be implemented in a computer program for recurrence design and to assist the realization of an optimized design of Faraday modulator coil.

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“…Power electronic resonant converter; 2. Air-core coil, which is the inductor part of resonant tank of converter [25,26].…”

Section: Introductionmentioning

confidence: 99%

Design of Alternating Magnetic Field Generator for Magnetic Fluid Hyperthermia Research Application

Mohseni

Rajaei

2017

Scientia Iranica

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Abstract. Hyperthermia utilizing nanoparticles is a novel cancer therapy, which relies on the heat released when nanoparticles inside a tumor are exposed to an alternating magnetic eld. The eld strength and frequency as the main variants a ect performance of nanoparticles in heat generation. Besides characteristics of the nanoparticle, which are the main criteria for tuning amplitude and frequency of the magnetic eld generated by an Alternating Magnetic Field Generator (AMFG), several related parameters should be considered for an optimum design of AMFG. These parameters are input voltage range, copper tube resistance used in solenoid coil, coil number of turns, etc. With regard to these criteria, a design procedure of AMFG for research applications is proposed to maximize the heat released by nanoparticles. In order to validate the design, an experimental setup of AMFG is prepared, which is used for in vivo hyperthermia tests. The experimental results are shown and compared with the simulations.

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Modified Solenoid Coil That Efficiently Produces High Amplitude AC Magnetic Fields With Enhanced Uniformity for Biomedical Applications

Cited by 74 publications

References 22 publications

Characterization of intratumor magnetic nanoparticle distribution and heating in a rat model of metastatic spine disease

Characterization of intratumor magnetic nanoparticle distribution and heating in a rat model of metastatic spine disease

Design and Analysis of Multilayer Solenoid Coil for Faraday Modulator

Design of Alternating Magnetic Field Generator for Magnetic Fluid Hyperthermia Research Application

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