Modified Starch-Based Hydrogels Cross-Linked with Citric Acid and their use as Drug Delivery Systems for Levofloxacin

Uliniuc, Ancuta; Hamaide, Thierry; Popa, Marcel; Bācāiţā, Simona

doi:10.1080/1539445x.2012.710698

Cited by 68 publications

(33 citation statements)

References 21 publications

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“…There might also be involvement of the primary -OH groups of the polysaccharides as they are more reactive than the secondary -OH groups, in the esterification process. Crosslinking generally occurred under dry state and required high temperatures for the reaction [11] . On the other hand evaporation of water, which is the first step in crosslinking with citric acid, is promoted by the hydrophobic character of the substrate.…”

Section: Resultsmentioning

confidence: 99%

“…The physically crosslinked hydrogels are mechanically weak and change in the environmental parameters such as pH, temperature or ionic strength may disrupt the network structure of the hydrogels [15] . The chemically crosslinked hydrogels are strong but the crosslinking agents used for their preparation are reported to be toxic [11] . In past few years, citric acid has emerged as a non-toxic crosslinking agent for the preparation of the hydrogels [16,17] .…”

Section: Research Papermentioning

confidence: 99%

“…Besides, the natural polymers are cheap as compared to the synthetic polymers. Some of the well-known natural polymers used for the preparation of hydrogels include cellulose [10] , starch [11] , chitosan [12] , sodium alginate [13] , guar gum [8] , gellan gum [14] and xanthan gum [7] .…”

Section: Research Papermentioning

confidence: 99%

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Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

104

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Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: Research Papermentioning

confidence: 99%

See 1 more Smart Citation

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

104

View full text Add to dashboard Cite

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“…8 As the polymer precursor is synthesized in advance, neither an oxygen-free environment nor removal procedures of monomers and initiators are required, and the crosslinking density can be easily controlled by the number of crosslinking functional groups. 12,13 The high efficiency of "click chemistry" resulted in well-defined network structures. 9,10 In the past decade, click reactions 11 have been perfect candidates to meet these criteria, and have found applications in hydrogel preparation.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21][22][23][24] Using residual functional groups in the hydrogels, Xu and coworkers 19 successfully implemented post-functionalizations by click reactions. 13 Besides the toxicity resulted from the reaction, great care must be taken while handling the highly explosive sodium azide, which is indispensable in the modification of the polymer precursors or crosslinking agents. See DOI: 10.1039/c5py01299f the synthesis of hydrogels owing to their high efficiency and tolerance to various functional groups, it has to be pointed out that some click reactions, such as the 1,3-dipolar cycloaddition, are catalyzed by metal ions, which are toxic and should be removed before being used for medical and biological purposes.…”

Section: Introductionmentioning

confidence: 99%

Reductant-triggered rapid self-gelation and biological functionalization of hydrogels

Chen

Wu²,

Cheng³

et al. 2015

Polym. Chem.

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Hydrogels have found wide applications in many fields. Although plenty of mature preparation methodologies are available now, there is certainly a continuous impetus in developing new methods toward simplicity, adjustability and satisfying diverse emerging needs. In this paper, a novel and efficient approach for hydrogel preparation is proposed. Polyacrylamide (PAM) chains with pyridyl disulfide (PDS) side groups were synthesized by free-radical polymerization. Upon addition of a tiny amount of reductants to the aqueous solution of the synthesized copolymer, part of the PDS groups are reduced to free thiols, and the subsequent exchange reaction between thiol groups and PDS results in disulfide-crosslinked hydrogels. The rapid self-gelation process was monitored by in situ rheological measurements, and the network structures of the hydrogels were observed using a scanning electron microscope. It has been found that the mechanical properties and pore sizes of the hydrogels could be tuned by changing the polymer concentration and the amounts of the reductants added into the solution. The residual PDS groups in the hydrogels provide reaction sites for immobilization of biological functional molecules.Reduced glutathione and bovine serum albumin were successfully immobilized in the hydrogels, and the bioactivities of the hydrogels were measured in this research. The disulfide crosslinks are cleavable and the hydrogels are dissociated under reducing conditions, which indicates that the hydrogels may find potential applications in biological and medical fields.Scheme 1 (a) Chemical reactions in the process of the reductanttriggered self-gelation; (b) illustration of the self-gelation and post-functionalization process. PaperPolymer ChemistryPolym. Chem. This journal is

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Fabrication of citric acid crosslinked β‐cyclodextrin/hydroxyethylcellulose hydrogel films for controlled delivery of poorly soluble drugs

Ghorpade

Yadav

Dias

et al. 2018

J of Applied Polymer Sci

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β‐cyclodextrin grafted hydroxyethylcellulose (βCD‐g‐HEC) hydrogel films were prepared for the controlled release of poorly soluble model drug (ketoconazole) using citric acid as crosslinking agent. The active βCD and carboxyl content of the hydrogel films were determined by phenolphthalein assay and acid–base titration. The films were characterized by solid state 13C NMR, ATR–FTIR, thermogravimetric analysis, and differential scanning calorimetric, and analyzed for tensile strength, swelling ratio, drug loading, release, hemocompatibility, in vitro cytotoxicity, and implantation test. An increase in the concentration of βCD in feed increased the active βCD content of the hydrogel films but reduced their extent of interpolymer crosslinking. The βCD‐g‐HEC hydrogel films with high active βCD content showed maximum drug loading whereas those with high crosslinking density were capable of controlling the drug release for long duration. Hemolysis assay and in vitro cytotoxicity study revealed the biocompatible nature of the hydrogel films whereas implantation test indicated their minimal inflammatory effect. From the overall results, βCD‐g‐HEC hydrogel films were found to be better alternative to the previously reported βCD‐HPMC and βCD‐CMC hydrogel films for enhanced loading and long‐term release, respectively, of the poorly soluble drugs. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46452.

show abstract

Modified Starch-Based Hydrogels Cross-Linked with Citric Acid and their use as Drug Delivery Systems for Levofloxacin

Cited by 68 publications

References 21 publications

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Reductant-triggered rapid self-gelation and biological functionalization of hydrogels

Fabrication of citric acid crosslinked β‐cyclodextrin/hydroxyethylcellulose hydrogel films for controlled delivery of poorly soluble drugs

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