1974
DOI: 10.1016/0022-4731(74)90051-x
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Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications

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Cited by 142 publications
(44 citation statements)
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“…2) (Liddle et al 1959) and 17a-, 18-, and 19-hydroxylase (Table 4) (Gower 1974). Cortisol levels decrease after 2 h of the first dose (Verhelst et al 1991).…”
Section: Metyraponementioning
confidence: 99%
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“…2) (Liddle et al 1959) and 17a-, 18-, and 19-hydroxylase (Table 4) (Gower 1974). Cortisol levels decrease after 2 h of the first dose (Verhelst et al 1991).…”
Section: Metyraponementioning
confidence: 99%
“…This observation led to the development of the use of o,p 0 -DDD or mitotane, initially for adrenal cancer and CS (Cueto & Brown 1958, Southren et al 1961. Subsequently, amphonenone B , Thorn et al 1956), aminoglutethimide (Camacho et al 1967), metyrapone (Gower 1974), trilostane (Potts et al 1978), and ketoconazole (Pont et al 1982) were identified as steroidogenic inhibitors ( Fig. 2 and Table 3).…”
Section: Adrenal Steroidogenesis Blockersmentioning
confidence: 99%
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“…Women were then followed in the Endocrinology Clinic every other week for the first 3 mo and monthly thereafter. Blood samples were collected between 8 and 9 a.m. and urine samples 24 4 Surgical adrenalectomny. § A4-A and DHT = 10 wk.…”
Section: Methodsmentioning
confidence: 99%
“…Aminoglutethimide has been shown to alter certain intraadrenal enzymne pathways such as A5to A4-isoMerase-3,8-ol dehydrogenase complex, the 11-and 21-hydroxylation reactions, and the conversion of cholesterol to pregnenolone (23)(24)(25). Because of these multiple effects, the androgen milieu in patients treated with aminoglutethimide could differ greatly from that produced by surgical removal of the adrenals or pituitary.…”
Section: Introductionmentioning
confidence: 99%