Modifying release characteristics from 3D printed drug-eluting products

Boetker, Johan; Water, Jorrit J.; Aho, Johanna; Arnfast, Lærke; Bohr, Adam; Rantanen, Jukka

doi:10.1016/j.ejps.2016.03.013

Cited by 133 publications

(85 citation statements)

References 27 publications

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“…An example is the use of polylactic acid as a drug eluting implant for slow and partial drug release of the antibiotics nitrofurantoin and hydroxyapatide. 25,42 Poly(vinyl) alcohol has also been used as a drug carrier for the investigation on the effects of geometry on drug release from 3D printed tablets. 43 In fact, poly(vinyl) alcohol has been used as a drug carrier for aminosalicylate modified-release tablets, 44 prednisolone extendedrelease tablets, 45 and budesonide modified-release tablets.…”

Section: Limitationsmentioning

confidence: 99%

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim

Chia

Kang

et al. 2016

Journal of Pharmaceutical Sciences

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Section: Limitationsmentioning

confidence: 99%

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim

Chia

Kang

et al. 2016

Journal of Pharmaceutical Sciences

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“…Previous reports suggested the need for using high temperatures [220 o C (8), 210 o C (9) and 250 o C (7)] when PVA based dosage forms were fabricated using FDM 3D printers. Moreover, several examples of PLA printed stuctures employed a temperature range of 180-210 o C (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

et al. 2016

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2 ABSTRACTPurpose. The fabrication of a ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.Methods. Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a capletshaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of drug and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.Results. Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication immediate release tablets at temperatures as low as 110 o C. The integrity of two models drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern. Conclusions.Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.

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“…3D printing is used to produce products like highly porous products (orally disintegrating), toroidal products (approximately zero-order release), Complex drug-device combination products, personalized dosing (for potent drugs and children), drug-loaded implants (matching the anatomy of individual patients), polypills (combination of different drugs) and ocular implant. 3D printing facilitates personalization by changing the digital designs which is more feasible than changing equipment design with less operational cost [10][11][12]. 3D printing is synonymously used with additive manufacturing and rapid prototyping technology.…”

Section: Procedures Advantages and Challenges Of 3d Printingmentioning

confidence: 99%

“…Additive manufacturing term is used for a group of technologies which construct the physical parts layer by layer addition of materials which is different from the conventional machining. There are various 3D printing methods employed for drug product manufacturing which are used based on the materials, equipment, and solidification shown in Figure 1 and Table 1 [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Procedures Advantages and Challenges Of 3d Printingmentioning

confidence: 99%

“…Hence, it requires to develop an alternative manufacturing approach, the best one would be coupling of FDM 3D printing and HME. There is need new bio-compatible/biodegradable polymers, which melts at lower temperatures or they could chemically functionalize polymeric filaments to increase drug loading and to avoid the potential instability of the incorporated drug [12,[31][32][33].…”

Section: Application Of Hme In 3d Printingmentioning

confidence: 99%

See 1 more Smart Citation

Application of Hot Melt Extrusion in Pharmaceutical 3D Printing

kushwaha¹

2018

J Bioequiv Availab

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3D printing is one of the rapid prototyping technology, which produces 3D products using layer-by-layer process from digital designs. 3D printing has gained a lot of attention in pharmaceutical industries since FDA approved a 3D-printed SPRITAM ® (levitracetam 1000 mg) fast dissolving tablets for the adjunct treatment of myoclonic seizures and primary generalized tonic-clonic seizures. There are various 3D printing methods employed for the drug product manufacturing which are used based on the materials, equipment, and solidification. Hot melt extrusion (HME) is one of the techniques which is used for 3D printing. This review article discusses the application of HME in 3D printing of pharmaceutical products. Uniting Hot melt extrusion (HME) for 3D printing with solid freeform fabrication (SFF) such as Fluid deposition method (FDM) offer great chances for designing a wide variety of drug delivery systems.

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Modifying release characteristics from 3D printed drug-eluting products

Cited by 133 publications

References 27 publications

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

Application of Hot Melt Extrusion in Pharmaceutical 3D Printing

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