Modifying somatosensory processing with non-invasive brain stimulation

Song, Sunbin; Sandrini, Marco; Cohen, Leonardo G.

doi:10.3233/rnn-2011-0614

Cited by 34 publications

(27 citation statements)

References 93 publications

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“…Studies investigating paired pulse TMS over S1 demonstrate amplified masking of a tactile sensation with a sub-threshold conditioning stimulus (Koch et al, 2006), and decreased sensorimotor performance with a suprathreshold conditioning stimulus (Meehan et al, 2008). Essentially, these foundational studies confirmed linkages between S1 activity and somatosensory processing (Song et al, 2011) and reinforced the theoretical potential of S1 as a target to modify more complex sensorimotor behaviors. However, the behavioral consequences of S1 stimulation are more applicable when considering the longer-lasting modulatory effects of neuromodulatory forms of TMS.…”

Section: Non-invasive Brain Stimulation (Nibs) Targeting S1 To Impsupporting

confidence: 68%

Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation

et al. 2015

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Emerging evidence indicates impairments in somatosensory function may be a major contributor to motor dysfunction associated with neurologic injury or disorders. However, the neuroanatomical substrates underlying the connection between aberrant sensory input and ineffective motor output are still under investigation. The primary somatosensory cortex (S1) plays a critical role in processing afferent somatosensory input and contributes to the integration of sensory and motor signals necessary for skilled movement. Neuroimaging and neurostimulation approaches provide unique opportunities to non-invasively study S1 structure and function including connectivity with other cortical regions. These research techniques have begun to illuminate casual contributions of abnormal S1 activity and connectivity to motor dysfunction and poorer recovery of motor function in neurologic patient populations. This review synthesizes recent evidence illustrating the role of S1 in motor control, motor learning and functional recovery with an emphasis on how information from these investigations may be exploited to inform stroke rehabilitation to reduce motor dysfunction and improve therapeutic outcomes.

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Section: Non-invasive Brain Stimulation (Nibs) Targeting S1 To Impsupporting

confidence: 68%

Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation

et al. 2015

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“…Because non-invasive brain stimulation targeting classically-defined somatosensory regions also modulates perception of spatial and temporal tactile stimulus features (Song et al, 2011), we propose that tactile perception is supported by distributed cortical networks that comprise somatosensory areas cooperating with visual and auditory areas. Anatomical connectivity studies have identified several pathways by which information potentially transfers between sensory systems (Cappe, Rouiller, & Barone, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Targeted enhancement or disruption of neural activity can acutely affect motor, sensory, and cognitive processes and can also induce specific functional changes that persist after the cessation of stimulation (Cohen Kadosh, Levy, O'Shea, Shea, & Savulescu, 2012; Nitsche et al, 2008; Nitsche & Paulus, 2011). In the sensory domain, both spatial and temporal touch are modulated by tDCS application over somatosensory cortex (Song, Sandrini, & Cohen, 2011). Here, we adopted tDCS strategies used for modulating visual and auditory function to investigate the contributions of visual and auditory areas to spatial and temporal touch.…”

Section: Introductionmentioning

confidence: 99%

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et al. 2014

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We perceive spatial form and temporal frequency by touch. Although distinct somatosensory neurons represent spatial and temporal information, these neural populations are intermixed throughout the somatosensory system. Here, we show that spatial and temporal touch can be dissociated and separately enhanced via cortical pathways that are normally associated with vision and audition. In Experiments 1 and 2, we found that anodal transcranial direct current stimulation (tDCS) applied over visual cortex, but not auditory cortex, enhances tactile perception of spatial orientation. In Experiments 3 and 4, we found that anodal tDCS over auditory cortex, but not visual cortex, enhances tactile perception of temporal frequency. This double-dissociation reveals separate cortical pathways that selectively support spatial and temporal channels. These results bolster the emerging view that sensory areas process multiple modalities and suggest that supramodal domains may be more fundamental to cortical organizational.

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“…These techniques, applied over the sensorymotor cortex have been shown to be beneficial in treating chronic pain associated with injury. 36,37 …”

Section: Discussionmentioning

confidence: 99%

Peripheral Nerve Injury Induces Immediate Increases in Layer V Neuronal Activity

Han

Zeiler

et al. 2013

Neurorehabil Neural Repair

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Background Peripheral nerve injury leads to changes in neuronal activity in the contralateral and ipsilateral primary somatosensory cortices (S1), which may lead to enduring sensory dysfunction and pain. Plasticity in the barrel and visual cortices has been shown to occur in a layer-specific manner. However, little is known about the layer specific changes associated with limb injury. Objective To determine the layer-specific changes in neuronal activity associated with short-term plasticity induced by peripheral nerve injury in the rat. Methods In vivo electrophysiology recordings (multiunit activity and local field potential) and high-resolution functional magnetic resonance imaging techniques were applied to characterize neuronal and hemodynamic responses across the depth of S1 contralateral and ipsilateral to the injury. Results Within 60 minutes following injury, atypical increases in neuronal and hemodynamic responses in the deprived S1, ipsilateral to the noninjured limb, were observed in response to stimulation of the noninjured limb. The most prominent increases in neuronal activity in the deprived S1 occurred in layer V. Conclusion Layer V neurons provide the major output of S1 and they send and receive transcallosal input. Thus, the immediate changes in neuronal firing patterns in layer V induced by the injury, can adversely affect the activity of subcortical regions and also interfere with normal cortical processing and interhemispheric communication. Therefore, a rehabilitation strategy that targets layer V neurons activity and starts immediately after the injury may benefit the functional outcome.

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Modifying somatosensory processing with non-invasive brain stimulation

Cited by 34 publications

References 93 publications

Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation

Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation

Feeling Better

Peripheral Nerve Injury Induces Immediate Increases in Layer V Neuronal Activity

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