Modifying the maker: Oxygenases target ribosome biology

Zhuang, Qinqin; Feng, Tianshu; Coleman, Mathew L.

doi:10.1080/21690731.2015.1009331

Cited by 9 publications

(11 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the finding that MINA and NO66 are related to YcFD, an Escherichia coli JmjC 2OG-oxygenase that catalyzes arginyl hydroxylation of the ribosomal protein Rpl16 [ 6 ], suggests that ribosomal oxygenase activity is very highly conserved. The function of MINA, NO66 and YcfD in ribosomal protein hydroxylation is consistent with an emerging role for JmjC-only enzymes, and the wider 2OG-oxygenase family, in protein translation [ 43 ].…”

Section: Assigning the Biochemical Activity Of Mina And No66mentioning

confidence: 61%

The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

Bundred

Hendrix

Coleman

2018

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Hydroxylation is a novel protein modification catalyzed by a family of oxygenases that depend on fundamental nutrients and metabolites for activity. Protein hydroxylases have been implicated in a variety of key cellular processes that play important roles in both normal homeostasis and pathogenesis. Here, in this review, we summarize the current literature on a highly conserved sub-family of oxygenases that catalyze protein histidyl hydroxylation. We discuss the evidence supporting the biochemical assignment of these emerging enzymes as ribosomal protein hydroxylases, and provide an overview of their role in immunology, bone development, and cancer.

show abstract

Section: Assigning the Biochemical Activity Of Mina And No66mentioning

confidence: 61%

The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

Bundred

Hendrix

Coleman

2018

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…MINA 53, NO66, OGFOD1 and Jmjd4 each hydroxylate proteins associated with the translational machinery, but they still appear to function efficiently, even in severely hypoxic conditions (Zhuang et al . ).…”

Section: Hypoxia‐responsive Transcriptional Regulationmentioning

confidence: 97%

Respiratory gases and the regulation of transcription

Cummins

Keogh

2016

Experimental Physiology

View full text Add to dashboard Cite

Eoin obtained a bachelor's degree in Pharmacology (2002) and a PhD (2007) from University College Dublin (UCD). During his postdoctoral career, Eoin became interested in the potential role for carbon dioxide as a modulator of inflammatory and immune signalling, in particular in relation to nuclear factor-κB signalling. The first paper on this work was published in the Journal of Immunology in 2010. In 2013, Eoin obtained his first faculty position as a Lecturer/Assistant Professor in Physiology in the School of Medicine UCD, and he currently leads a research group focused on the effects of hypercapnia on inflammation and immunity. New Findings r What is the topic of this review? This review highlights the transcriptional consequences for decreased cellular O 2 levels (hypoxia) and increased cellular CO 2 levels (hypercapnia). r What advances does it highlight?We discuss recent advances in our understanding of the cellular response to hypoxia and consider the potential cross-talk between O 2 -and CO 2 -dependent transcriptional regulation.Oxygen and carbon dioxide are the substrate and product of aerobic metabolism, respectively. Thus, the levels of these physiological gases are inextricably linked in physiological and pathophysiological conditions. Increased mitochondrial consumption of O 2 (to produce ATP) will produce more CO 2 . Furthermore, in lung pathologies such as chronic obstructive pulmonary disease, sleep apnoea and central hypoventilation syndrome, hypoxia and hypercapnia are co-incident. Acute responses to hypoxia involve carotid body-mediated changes in the rate and depth of breathing. Chronic adaptation to hypoxia involves a multitude of changes on a transcriptional level, which simultaneously increases oxygen utilization (via hypoxia-inducible factor and others), while suppressing superfluous energy-demanding processes. Acute responses to CO 2 affect breathing primarily via central chemoreceptors. The nature of hypercapnia-dependent transcriptional regulation is an emerging area of research, but at present the mechanisms underpinning this response are not fully characterized and understood. Thus, given the juxtaposition of hypoxia and hypercapnia in health and disease, this manuscript reviews the current evidence for transcriptional responses to hypoxia and hypercapnia. Finally, we discuss the potential cross-talk between hypoxia and hypercapnia on a transcriptional level.

show abstract

“…Translation factors also are hydroxylated by these enzymes [43]. Elongation factor-Tu (EF-Tu) and elongation factor-1A form a complex that binds to the aminoacyl-tRNA delivering an amino acid to the A site within the mature ribosome.…”

Section: Relationship Of 2og-dependent Oxygenases To the Central Dogmamentioning

confidence: 99%

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

Herr

Hausinger

2018

Trends in Biochemical Sciences

180

173

View full text Add to dashboard Cite

Since their discovery in the 1960s, the family of Fe(II)/2-oxoglutarate-dependent oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast diversity of biologically important reactions. Recent examples highlight roles in controlling chromatin modification, transcription, mRNA demethylation, and mRNA splicing. Others generate modifications in tRNA, translation factors, ribosomes, and other proteins. Thus, oxygenases affect all components of molecular biology's central dogma, in which information flows from DNA to RNA to proteins. These enzymes also function in biosynthesis and catabolism of cellular metabolites, including antibiotics and signaling molecules. Due to their critical importance, ongoing efforts have targeted family members for the development of specific therapeutics. This review provides a general overview of recently characterized oxygenase reactions and their key biological roles.

show abstract

Modifying the maker: Oxygenases target ribosome biology

Cited by 9 publications

References 111 publications

The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

Respiratory gases and the regulation of transcription

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

Contact Info

Product

Resources

About