2018
DOI: 10.1007/s11682-018-0019-6
|View full text |Cite
|
Sign up to set email alerts
|

Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer’s disease

Abstract: Mild cognitive impairment (MCI) is a heterogeneous condition with variable outcomes. Improving diagnosis to increase the likelihood that MCI reliably reflects prodromal Alzheimer's Disease (AD) would be of great benefit for clinical practice and intervention trials. In 230 cognitively normal (CN) and 394 MCI individuals from the Alzheimer's Disease Neuroimaging Initiative, we studied whether an MCI diagnostic requirement of impairment on at least two episodic memory tests improves 3-year prediction of medial t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
6
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 15 publications
(6 citation statements)
references
References 39 publications
0
6
0
Order By: Relevance
“…In addition, despite that neuropsychological and volumetric measures showed clear and systematic differences across the groups (as expected based on the standard diagnostic criteria used by the ADNI), it should be considered that subsequent modifications to the diagnostic criteria may yield some miss-classification when compared to the initial baseline rollover of the ADNI3 phase [ 161 , 162 , 163 ], since MCI criteria for diagnosis are constantly being reviewed and scrutinized [ 164 ]. However, TMT-A performances of HC group are within the normative values for their age and education, suggesting that there is no evidence of behavioural impairment, at least based on normative scores for the TMT-A, suggesting no evidence of impairment in this group [ 165 ].…”
Section: Limitationsmentioning
confidence: 99%
“…In addition, despite that neuropsychological and volumetric measures showed clear and systematic differences across the groups (as expected based on the standard diagnostic criteria used by the ADNI), it should be considered that subsequent modifications to the diagnostic criteria may yield some miss-classification when compared to the initial baseline rollover of the ADNI3 phase [ 161 , 162 , 163 ], since MCI criteria for diagnosis are constantly being reviewed and scrutinized [ 164 ]. However, TMT-A performances of HC group are within the normative values for their age and education, suggesting that there is no evidence of behavioural impairment, at least based on normative scores for the TMT-A, suggesting no evidence of impairment in this group [ 165 ].…”
Section: Limitationsmentioning
confidence: 99%
“…Supraspan verbal list‐learning tests (VLTs) are standard neuropsychological measures for assessing verbal declarative memory in aging and clinical studies. VLTs are also efficient in identifying or predicting conversion to AD (Bauer, Cabral, & Killiany, 2018; Cerami et al, 2017; Estévez‐González, Kulisevsky, Boltes, Otermín, & García‐Sánchez, 2003; Fleisher et al, 2008; Gleason et al, 2017; Goryawala et al, 2015; Moradi, Hallikainen, Hänninen, & Tohka, 2017; Vuoksimaa et al, 2018), to the extent of being considered markers of hippocampal integrity (Saury & Emanuelson, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Structural MRI (sMRI) cortical and subcortical measurements, e.g., thickness and rs-fMRI functional graph connectivity biomarkers, were studied with SVM classification having high prediction accuracy for MCI converter or non-converter ( Cabral et al, 2015 ). Vuoksimaa et al (2020) investigated on vascular risk factors, serving as a biomarker, for MCI to AD conversion in subjects having low cerebral small vessel burden. Memory baseline brain (e.g., hippocampus, entorhinal cortex) and CSF biomarkers were also studied by Kung et al (2020) .…”
Section: Introductionmentioning
confidence: 99%