“…54,55 However, some of the resulting peptides might also be toxic because some of the properties neglected for their design, such as hydrophobic-related features, lead to high affinity towards eukaryotic membranes. 56 Design strategies are now taking into consideration more complex descriptors, and the AMPs generated de novo are more selective for prokaryotic cells, 39,57,58 not only for antimicrobial purposes but for other biochemical processes, such as peptide substrates for enzymes 59 that affect essential biochemical pathways of prokaryotic microorganisms. The in silico exploration have allowed to expand the usefulness of peptides for other technological uses.…”