We prove a "height-free" effective isogeny estimate for abelian varieties of GL2-type.More precisely, let g ∈ Z + , K a number field, S a finite set of places of K, and A, B/K g-dimensional abelian varieties with good reduction outside S which are K-isogenous and of GL2-type over Q. We show that there is a K-isogeny A → B of degree effectively bounded in terms of g, K, and S only.We deduce among other things an effective upper bound on the number of S-integral K-points on a Hilbert modular variety.Contents.