Modulated cellular delivery of anti-VEGF siRNA (bevasiranib) by incorporating supramolecular assemblies of hydrophobically modified polyamidoamine dendrimer in stealth liposomes

Golkar, Nasim; Mohammadi-Samani, Soliman; Tamaddon, Ali Mohammad

doi:10.1016/j.ijpharm.2016.06.026

Cited by 28 publications

(23 citation statements)

References 86 publications

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“…of the DNA at all tested ratios for the low-cholesterol dendrimer, and at dendrimer: DNA weight ratios of 1:1 and higher for the high-cholesterol dendrimer, which displayed less primary amines at its periphery than its low-cholesterol counterpart ( Figures 7A and B). DNA condensation occurred instantly and was found to be stable for at least 24 h. DNA condensing ability of these modified dendrimers was of the same range to that reported for generations 1, 2 and 3-PAMAM dendrimers conjugated to 40% cholesterol, [30][31] PEGylated poly(amidoamine) dendron-bearing lipids-based lipoplexes, 16 octadecyl alkyl chain-bearing generations 2-and 3-PAMAM dendrons forming lipoplexes following probe sonication 46 (up to 100% for all of these formulations).…”

Section: Evaluation Of Dna Condensationsupporting

confidence: 71%

“…30 They were lower than the CMC observed when using generation-3 PAMAM dendrimers conjugated to cholesterol at 6% and 15% mole ratio of cholesterol/primary amine (respectively 86.6 ± 5.6 µg/mL and 50.2 ± 5.1 µg/mL). 31 These low CMC facilitated the incorporation of the PAMAM-cholesterol in the PEG-stabilized liposome bilayer. In addition, the CAC values for the low-and high-cholesterol dendrimers were found to be well below those of dendrimersomes and glycodendrimersomes prepared from self-assembling amphiphilic Janus dendrimers (typically between 0.5 mg/mL and 1 mg/mL).…”

Section: Evaluation Of the Self-assembly Formation Of The Dendrimersmentioning

confidence: 99%

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Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells

et al. 2018

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Section: Evaluation Of Dna Condensationsupporting

confidence: 71%

Section: Evaluation Of the Self-assembly Formation Of The Dendrimersmentioning

confidence: 99%

Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells

et al. 2018

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“…These nanoparticles encapsulate antigens within their cores and then deliver them to the target cells. Lipidation leads to the formation of amphiphiles, which improve diffusion across epithelial barriers and provide stability against degradation agents (Golkar et al, 2016a(Golkar et al, , 2016bZhao et al, 2014). These structures target vaccines to DCs and stimulate the activation of these cells through self-adjuvant properties.…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Negahdaripour

Golkar

Hajighahramani

et al. 2017

Biotechnology Advances

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107

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Vaccination has been one of the most successful breakthroughs in medical history. In recent years, epitope-based subunit vaccines have been introduced as a safer alternative to traditional vaccines. However, they suffer from limited immunogenicity. Nanotechnology has shown value in solving this issue. Different kinds of nanovaccines have been employed, among which virus-like nanoparticles (VLPs) and self-assembled peptide nanoparticles (SAPNs) seem very promising. Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility. They also resemble pathogens in terms of their size. Their multivalency allows an orderly repetitive display of antigens on their surface, which induces a stronger immune response than single immunogens. In vaccine design, SAPN self-adjuvanticity is regarded an outstanding advantage, since the use of toxic adjuvants is no longer required. SAPNs are usually composed of helical or β-sheet secondary structures and are tailored from natural peptides or de novo structures. Flexibility in subunit selection opens the door to a wide variety of molecules with different characteristics. SAPN engineering is an emerging area, and more novel structures are expected to be generated in the future, particularly with the rapid progress in related computational tools. The aim of this review is to provide a state-of-the-art overview of self-assembled peptide nanoparticles and their use in vaccine design in recent studies. Additionally, principles for their design and the application of computational approaches to vaccine design are summarized.

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“…Guo and his team demonstrated that Lcn2 siRNA loaded ICAM-1-targeting liposomes showed a potent antiangiogenic effect in triple-negative breast cancer (TNBC) [79]. Several other research groups also developed similar lipid-based NPs for gene-mediated angiogenesis inhibition [80][81][82][83][84][85][86][87]. Sorafenib inhibits angiogenesis and proliferation via binding to VEGFR-2, VEGFR-3, and PDGFR-b tyrosine kinases.…”

Section: Lipid-based Nanoparticles For Antiangiogenic Therapymentioning

confidence: 99%

Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer

Mukherjee¹,

Madamsetty

Paul

et al. 2020

IJMS

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Angiogenesis is a process of generation of de-novo blood vessels from already existing vasculature. It has a crucial role in different physiological process including wound healing, embryonic development, and tumor growth. The methods by which therapeutic drugs inhibit tumor angiogenesis are termed as anti-angiogenesis cancer therapy. Developments of angiogenic inhibiting drugs have various limitations causing a barrier for successful treatment of cancer, where angiogenesis plays an important role. In this context, investigators developed novel strategies using nanotechnological approaches that have demonstrated inherent antiangiogenic properties or used for the delivery of antiangiogenic agents in a targeted manner. In this present article, we decisively highlight the recent developments of various nanoparticles (NPs) including liposomes, lipid NPs, protein NPs, polymer NPs, inorganic NPs, viral and bio-inspired NPs for potential application in antiangiogenic cancer therapy. Additionally, the clinical perspectives, challenges of nanomedicine, and future perspectives are briefly analyzed.

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Modulated cellular delivery of anti-VEGF siRNA (bevasiranib) by incorporating supramolecular assemblies of hydrophobically modified polyamidoamine dendrimer in stealth liposomes

Cited by 28 publications

References 86 publications

Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells

Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer

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