Modulated expression of human leucocyte antigen class I and class II determinants in hyperplastics and malignant human prostatic epithelium

Sharpe, Julia; Abel, Paul; Gilbertston, J.A.; Brawn, Peter N.; Foster, Christopher S.

doi:10.1111/j.1464-410x.1994.tb09193.x

Cited by 36 publications

(29 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with earlier reports: for instance Sharpe et al concluded that expression of MHC class I and II determinants (such as B2M) was downregulated in tissue samples from PCa patients. 41 While B2M expression is downregulated, HLA-A expression does not differ significantly in our results. Tamura et al concluded that expression of HLA-A is downregulated when PCa cells progress from hormone therapy sensitive to hormone resistant PCa.…”

Section: 33mentioning

confidence: 32%

“…Although it is generally accepted that the immune system plays a role in PCa, the exact mechanism by which the immune system is involved in PCa initiation, progression and treatment remains unclear. 41,44 Sipuleucel-T has been approved by the US FDA as a cellular immunotherapy that improves overall survival in asymptomatic or minimally symptomatic metastatic castrate-resistant PCa patients, and other immunotherapies such as ipilimumab are in advanced stages of clinical development. 45,46 However, some have doubted its efficacy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

et al. 2013

View full text Add to dashboard Cite

histone deacetylases (hDacs) have emerged as important targets for cancer treatment. hDac-inhibitors (hDacis) are well tolerated in patients and have been approved for the treatment of patients with cutaneous T-cell lymphoma (cTcL).To improve the clinical benefit of hDacis in solid tumors, combination strategies with hDacis could be employed. In this study, we applied analysis of Functional annotation (aFa) to provide a comprehensive list of genes and pathways affected upon hDaci-treatment in prostate cancer cells. This approach provides an unbiased and objective approach to high throughput data mining. By performing aFa on gene expression data from prostate cancer cell lines DU-145 (an hDaci-sensitive cell line) and pc3 (a relatively hDaci-resistant cell line) treated with hDacis valproic acid or vorinostat, we identified biological processes that are affected by hDacis and are therefore potential treatment targets for combination therapy. Our analysis revealed that hDac-inhibition resulted among others in upregulation of major histocompatibility complex (Mhc) genes and deregulation of the mitotic spindle checkpoint by downregulation of genes involved in mitosis. These findings were confirmed by aFa on publicly available data sets from hDaci-treated prostate cancer cells. In total, we analyzed 375 microarrays with hDaci treated and non-treated (control) prostate cancer cells. all results from this extensive analysis are provided as an online research source (available at the journal's website and at http:// luigimarchionni.org/hDacIs.html). By publishing this data, we aim to enhance our understanding of the cellular changes after hDac-inhibition, and to identify novel potential combination strategies with hDacis for the treatment of prostate cancer patients. Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

show abstract

Section: 33mentioning

confidence: 32%

Section: Discussionmentioning

confidence: 99%

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Expression of MHC class II molecules has been previously observed in BPH specimens (10,21), although not consistently (22), but expression of costimulatory molecules by BPH has never been reported so far. Many cytokines have been shown to be produced by BPH cells (7), but not cytokines directing or amplifying the differentiation of pathogenic T cells such as IL12p75 and IL-23, although BPH-derived T cells have been demonstrated to produce IL-17 (13).…”

Section: Discussionmentioning

confidence: 92%

Human Benign Prostatic Hyperplasia Stromal Cells As Inducers and Targets of Chronic Immuno-Mediated Inflammation

Penna

Fibbi

Amuchastegui³

et al. 2009

The Journal of Immunology

159

158

View full text Add to dashboard Cite

Benign prostatic hyperplasia (BPH), a highly prevalent prostatic condition, could involve an inflammatory component in disease pathogenesis. In this study, we show that human stromal prostate cells obtained from BPH tissue can actively contribute to the inflammatory process by secreting proinflammatory cytokines as well as chemokines able to recruit lymphomonuclear cells and by acting as APCs. BPH cells express all of the TLRs and their ligation leads to the secretion of CXCL8/IL-8, CXCL10, and IL-6. In addition, BPH cells express costimulatory as well as class I and class II MHC molecules, which activate alloreactive CD4+ cells that in turn markedly up-regulate IL-12/IL-23p40 and IL-12p75 secretion by BPH cells. Alloreactive CD4+ cells activated by BPH cells secrete IFN-γ and IL-17. These cytokines up-regulate IL-6, IL-8, and CXCL10 production by BPH cells, creating a positive feedback loop that can amplify inflammation. IL-8 induces autocrine/paracrine proliferation of BPH cells, indicating also a growth-promoting activity of this chemokine in disease pathogenesis. These results show that human BPH cells represent nonprofessional APCs able to induce and sustain chronic inflammatory processes, supporting the relevance of inflammation in BPH pathogenesis.

show abstract

“…Specimens were considered positive only when at least 5% of the specific tissue component was unequivocally stained. This cut-off has been previously employed to distinguish positive and negative immunohistochemical staining [23]. In cases judged positive, the subcellular location of staining was characterised as membranous or cytoplasmic and for the latter either diffuse or granular staining.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Detailed Tissue Expression of bcl-2, bax, bak and bcl-x in the Normal Human Pancreas and in Chronic Pancreatitis, Ampullary and Pancreatic Ductal Adenocarcinomas

et al. 2001

View full text Add to dashboard Cite

Modulated expression of human leucocyte antigen class I and class II determinants in hyperplastics and malignant human prostatic epithelium

Cited by 36 publications

References 29 publications

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

Human Benign Prostatic Hyperplasia Stromal Cells As Inducers and Targets of Chronic Immuno-Mediated Inflammation

Detailed Tissue Expression of bcl-2, bax, bak and bcl-x in the Normal Human Pancreas and in Chronic Pancreatitis, Ampullary and Pancreatic Ductal Adenocarcinomas

Contact Info

Product

Resources

About