Modulating and opposite actions of two aqueous extracts prepared from<i>Cinnamomum cassia</i>L. bark and<i>Quercus ilex</i>L. on the gastrointestinal tract in rats

Sebaï, Hichem; Rtibi, Kaïs; Selmi, Slimen; Jridi, Mourad; Balti, Rafik; Marzouki, Lamjed

doi:10.1039/c9ra02429h

Cited by 12 publications

(10 citation statements)

References 52 publications

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“…Among these laurel-derived ligands, lauruside 5 emerged from our study as the most promising candidate as a potential M pro inhibitor. Moreover, despite its lower binding affinity for the protease when compared to lauruside 5, kaempferol, a natural compound isolated not only from Laurus nobilis L. but also from other Mediterranean plants like Quercus Ilex L. (Sebai et al 2019 ), especially in glucosidated form (Karioti et al 2010 ), could act as a potentially effective M pro inhibitor. Remarkably, still showing an interesting predicted binding energy (− 7.4 kcal/mol for the top scoring pose), it is also endowed with an even more favourable predicted toxicity profile (Class V) than laurusides.…”

Section: Discussionmentioning

confidence: 99%

Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Roviello

2020

Environ Chem Lett

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The COVID-19 pandemic has induced dramatic effects on the population of the industrialized north of Italy, whereas it has not heavily affected inhabitants of the southern regions. This might be explained in part by human exposure to high levels of fine particulate matter (PM) in the air of northern Italy, thus exacerbating the mortality. Since trees mitigate air pollution by intercepting PM onto plant surfaces and bolster the human immune system by emitting bioactive volatile organic compounds (VOCs), we hypothesize a protective role of evergreen forested areas in southern Italy. We compared the mortality rate due to COVID-19, the death number, the positivity rate and the forest coverage per capita in various Italian regions. Hectares of forest per capita and prevalence of deciduous versus evergreen forestal species were also estimated. In silico docking studies of potentially protective compounds found in Laurus nobilis L., a typical Mediterranean plant, were performed to search for potential antivirals. We found that the pandemic's severity was generally lower in southern regions, especially those with more than 0.3 hectares of forest per capita. The lowest mortality rates were found in southern Italy, mainly in regions like Molise (0.007%) and Basilicata (0.005%) where the forest per capita ratio is higher than 0.5 Ha/person. Our findings suggest that evergreen Mediterranean forests and shrubland plants could have protected the southern population by emission of immunomodulating VOCs and provision of dietary sources of bioactive compounds. Moreover, in silico studies revealed a potential anti-COVID-19 activity in laurusides, which are unexplored glycosides from bay laurel. Overall, our results highlight the importance of nature conservation and applications to the search for natural antivirals.

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Section: Discussionmentioning

confidence: 99%

Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Roviello

2020

Environ Chem Lett

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“…Thus, this action of pacemaker potentiality depolarization could produce a GI-motility increase, as with diverse medicinal plants like Liriope platyphylla and Citrus unshiu. 59 …”

Section: Discussionmentioning

confidence: 99%

“…Thus, this action of pacemaker potentiality depolarization could produce a GI-motility increase, as with diverse medicinal plants like Liriope platyphylla and Citrus unshiu. 59 Decreased mucus generation in the mucosa of the colon is related with colonic slow transit and noted to reduce the colonic mucosal layer thickness, and the number of mucus-generating cells has been investigated by histopathological diagnosis in the constipated animals. In this context, in the treatment of animals with LP for a week, an alteration in the colon microscopical structure was detected in the present study.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent Action of Zingiber officinale on Colonic Dysmotility and Ex Vivo Spontaneous Intestinal Contraction Modulation

et al. 2022

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Ginger ( Zingiber officinale ) rhizomes are commonly used in foods and employed for many ailments including gastrointestinal disorders. Our main objective was to evaluate the effect of Zingiber officinale aqueous extract (ZOAE) on gastrointestinal (GI) physiological motility and colonic dysmotility. Thereby, Wistar rats were given loperamide (LP, 3 mg/kg, b.w.) and ZOAE (75, 150, and 300 mg/kg, b.w.) or yohimbine (YOH, 2 mg/kg, b.w.). ZOAE-action on intestinal secretion was assessed using Ussing chamber technique and intestinal motility with isometric transducer. GI-transit (GIT) and gastric emptying (GE) were evaluated with the charcoal meal test and the red phenol methods. ZOAE-bioactive components were analyzed by liquid chromatography-high resolution electrospray ionization mass spectrometry (LC-HRESIMS). Constipation was induced with LP and the different indicators such as stool composition, GIT, oxidative stress biological parameters, and colonic mucosa histological alteration were performed. Anti-constipation effect of ZOAE was confirmed on stool composition, GIT (53.42% to 85.57%), GE (55.47% to 98.88%), and re-established oxidative balance. ZOAE induces an amplitude increase of spontaneous intestinal contraction with EC50 of 10.52 μg/mL. No effect of ZOAE was observed on electrogenic transport of intestinal fluid. These findings suggest that ZOAE-bioactive candidates might exert an anti-constipation action and spontaneous intestinal contraction modulation.

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“…Therefore, tannins, which are present in cassia bark extract, are able to reduce the demand for food intake by delaying the digestion action and by delaying the digestive track emptying. Researchers have reported that cassia bark extract is helpful in different GI-related disorders like constipation, and diarrhea [ 815 ]…”

Section: Health Benefit Potentialmentioning

confidence: 99%

Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology

Mandal

Sarkar

Chakraborty

2022

Appl Biochem Biotechnol

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Medicinal or herbal spices are grown in tropical moist evergreen forestland, surrounding most of the tropical and subtropical regions of Eastern Himalayas in India (Sikkim, Darjeeling regions), Bhutan, Nepal, Pakistan, Iran, Afghanistan, a few Central Asian countries, Middle East, USA, Europe, South East Asia, Japan, Malaysia, and Indonesia. According to the cultivation region surrounded, economic value, and vogue, these spices can be classified into major, minor, and colored tropical spices. In total, 24 tropical spices and herbs (cardamom, black jeera, fennel, poppy, coriander, fenugreek, bay leaves, clove, chili, cassia bark, black pepper, nutmeg, black mustard, turmeric, saffron, star anise, onion, dill, asafoetida, celery, allspice, kokum, greater galangal, and sweet flag) are described in this review. These spices show many pharmacological activities like anti-inflammatory, antimicrobial, anti-diabetic, anti-obesity, cardiovascular, gastrointestinal, central nervous system, and antioxidant activities. Numerous bioactive compounds are present in these selected spices, such as 1,8-cineole, monoterpene hydrocarbons, γ-terpinene, cuminaldehyde, trans-anethole, fenchone, estragole, benzylisoquinoline alkaloids, eugenol, cinnamaldehyde, piperine, linalool, malabaricone C, safrole, myristicin, elemicin, sinigrin, curcumin, bidemethoxycurcumin, dimethoxycurcumin, crocin, picrocrocin, quercetin, quercetin 4’-O-β-glucoside, apiol, carvone, limonene, α-phellandrene, galactomannan, rosmarinic acid, limonene, capsaicinoids, eugenol, garcinol, and α-asarone. Other than that, various spices are used to synthesize different types of metal-based and polymer-based nanoparticles like zinc oxide, gold, silver, selenium, silica, and chitosan nanoparticles which provide beneficial health effects such as antioxidant, anti-carcinogenic, anti-diabetic, enzyme retardation effect, and antimicrobial activity. The nanoparticles can also be used in environmental pollution management like dye decolorization and in chemical industries to enhance the rate of reaction by the use of catalytic activity of the nanoparticles. The nutritional value, phytochemical properties, health advantages, and both traditional and modern applications of these spices, along with their functions in food fortification, have been thoroughly discussed in this review

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Modulating and opposite actions of two aqueous extracts prepared fromCinnamomum cassiaL. bark andQuercus ilexL. on the gastrointestinal tract in rats

Abstract: Cinnamon bark and evergreen oak acorns, natural sources of functional ingredients, are effective for those suffering from diarrhea, constipation and irritable bowel syndrome.

Cited by 12 publications

References 52 publications

Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Dose-dependent Action of Zingiber officinale on Colonic Dysmotility and Ex Vivo Spontaneous Intestinal Contraction Modulation

Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology

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