Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing

Zhang, Nihui; Gao, Tao; Wang, Yao; Liu, Juan; Zhang, Junwei; Yao, Ruijuan; Wu, Fang

doi:10.1016/j.ijbiomac.2020.03.161

Cited by 63 publications

(30 citation statements)

References 45 publications

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“…An imbalance in metal ions can also lead to scar growth. Modulating the cation in chitosan hydrogel or adding aloe gel can lead to effective scar inhibition ( Zhang N. et al, 2020 ). Chitosan hydrogels can also be used as hemostatic dressings.…”

Section: Drug Carriers Prepared Using Chitosan and Its Derivativesmentioning

confidence: 99%

“…Chitosan and its derivatives have been processed into hydrogels, sponges, microspheres, nanoparticles, and thin films for use as medical materials. These are widely used to treat different diseases, especially those of the skin and soft tissues, owing to the diverse properties of these compounds ( Ma et al, 2017 ; Zhang N. et al, 2020 ; El Kadib, 2020 ; Hou et al, 2020 ; He et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Chitosan and its derivatives are bioactive molecules that have recently been used in various fields, especially in the medical field. The antibacterial, antitumor, and immunomodulatory properties of chitosan have been extensively studied. Chitosan can be used as a drug-delivery carrier in the form of hydrogels, sponges, microspheres, nanoparticles, and thin films to treat diseases, especially those of the skin and soft tissue such as injuries and lesions of the skin, muscles, blood vessels, and nerves. Chitosan can prevent and also treat soft tissue diseases by exerting diverse biological effects such as antibacterial, antitumor, antioxidant, and tissue regeneration effects. Owing to its antitumor properties, chitosan can be used as a targeted therapy to treat soft tissue tumors. Moreover, owing to its antibacterial and antioxidant properties, chitosan can be used in the prevention and treatment of soft tissue infections. Chitosan can stop the bleeding of open wounds by promoting platelet agglutination. It can also promote the regeneration of soft tissues such as the skin, muscles, and nerves. Drug-delivery carriers containing chitosan can be used as wound dressings to promote wound healing. This review summarizes the structure and biological characteristics of chitosan and its derivatives. The recent breakthroughs and future trends of chitosan and its derivatives in therapeutic effects and drug delivery functions including anti-infection, promotion of wound healing, tissue regeneration and anticancer on soft tissue diseases are elaborated.

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Section: Drug Carriers Prepared Using Chitosan and Its Derivativesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…The CS hydrogel revealed the potential to prevent scar formation through lower levels of α-Smooth muscle actin (α-SMA) expression and a wound closure rate of 93.8 ± 1.4% after 14 days. Further, a smoother and better appearance was highlighted in the SD rat model after co-treatment with carboxymethyl CS and aloe vera gel [20]. Modified N-carboxymethyl CS expressed less inflammation by activating the transforming growth factor-β1 (TGF-β1)/Smad3 signaling in the Wistar rat model [21].…”

Section: Polysaccharide Scaffoldmentioning

confidence: 99%

Advances in Skin Wound and Scar Repair by Polymer Scaffolds

et al. 2021

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Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.

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“…There are a variety of biomaterials that can be used as matrices for wound healing purposes and can be categorised as either natural or synthetic. The most utilised natural biomaterials for wound management are collagen, gelatine, hyaluronic acid, alginate, chitosan, fibrin, cellulose and silk fibroin [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. They are substantially discovered in the ECM arrangements with properties of bioinert, biodegradable, and possess strength and elasticity that are applicable for the use of tissue engineering and cell culture [ 45 , 46 , 47 , 48 ].…”

Section: Development Of Injectable Hydrogel For Diabetic Foot Managementmentioning

confidence: 99%

Injectable Hydrogels for Chronic Skin Wound Management: A Concise Review

Mazlan

2021

Biomedicines

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Diabetic foot ulcers (DFU) are a predominant impediment among diabetic patients, increasing morbidity and wound care costs. There are various strategies including using biomaterials have been explored for the management of DFU. This paper will review the injectable hydrogel application as the most studied polymer-based hydrogel based on published journals and articles. The main key factors that will be discussed in chronic wounds focusing on diabetic ulcers include the socioeconomic burden of chronic wounds, biomaterials implicated by the government for DFU management, commercial hydrogel product, mechanism of injectable hydrogel, the current study of novel injectable hydrogel and the future perspectives of injectable hydrogel for the management of DFU.

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Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing

Cited by 63 publications

References 45 publications

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Advances in Skin Wound and Scar Repair by Polymer Scaffolds

Injectable Hydrogels for Chronic Skin Wound Management: A Concise Review

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