Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients

Matijašić, Mario; Meštrović, Tomislav; Perić, Mihaela; Paljetak, Hana Čipčić; Panek, Michał; Bender, Darija Vranešić; Kelečić, Dina Ljubas; Krznarić, Željko; Verbanac, Donatella

doi:10.3390/ijms17040578

Cited by 61 publications

(45 citation statements)

References 178 publications

(201 reference statements)

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“…Indeed, there is a large body of literature on the use of antibiotics and probiotics in IBD. While a full review of antibiotics and probiotics is beyond the scope of this article (especially given other excellent recent reviews), 78,79 several points are highlighted to demonstrate the importance of microbiota manipulation in IBD. The use of antibiotics has variable success for the treating IBD, although in one pooled analysis there was a trend toward benefit, particularly in fistulizing or post-surgical Crohn's disease.…”

Section: Clinical Use Of Fmt For Ibdmentioning

confidence: 99%

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

2017

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Inflammatory bowel disease (IBD) is a complex set of diseases that lead to chronic inflammation in the gastrointestinal tract. Although the etiology of IBD is not fully understood, it is well-known that the intestinal microbiota is associated with the development and maintenance of IBD. Manipulation of the gut microbiota, therefore, may represent a target for IBD therapy. Fecal microbiota transplantation (FMT), where fecal microbiota from a healthy donor is transplanted into a patient's GI tract, is already a successful therapy for Clostridium difficile infection. FMT is currently being explored as a potential therapy for IBD as well. In this review, the associations between the gut microbiota and IBD and the emerging data on FMT for IBD will be discussed.

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Section: Clinical Use Of Fmt For Ibdmentioning

confidence: 99%

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

2017

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“…Both are bioactive agents that function to suppress inflammation via a number of proposed mechanisms [5][6][7]. Hence, various probiotic and prebiotic agents are being increasingly explored to treat or prevent IBD in humans [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases

et al. 2020

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Purpose The research goal is to develop dietary strategies to help address the growing incidence of inflammatory bowel diseases (IBD). This study has investigated the effectiveness of green banana resistant starch (GBRS) and probiotic Bacillus coagulans MTCC5856 spores for the amelioration of dextran-sulfate sodium (DSS)-induced colitis in mice. Methods Eight-week-old C57BL/6 mice were fed standard rodent chow diet supplemented with either B. coagulans, GBRS or its synbiotic combination. After 7 days supplementation, colitis was induced by adding 2% DSS in drinking water for 7 days while continuing the supplemented diets. Animal health was monitored and after 14 days all animals were sacrificed to measure the biochemical and histochemical changes associated with each supplement type. Results The disease activity index and histological damage score for DSS-control mice (6.1, 17.1, respectively) were significantly higher (p < 0.0001) than the healthy mice. Synbiotic supplementation alleviated these markers (− 67%, − 94% respectively) more adequately than B. coagulans (− 52%, − 58% respectively) or GBRS (− 57%, − 26%, respectively) alone. Compared to DSS-control synbiotic supplementation significantly (p < 0.0001) maintained expressions of tight junction proteins. Moreover, synbiotic effects accounted for ~ 40% suppression of IL-1β and ~ 29% increase in IL-10 levels in serum while also reducing C-reactive protein (− 37%) compared to that of the DSS-control. While, B. coagulans alone could not induce additional levels of short-chain fatty acid (SCFA) production beyond the caecum, the synbiotic combination with GBRS resulted in substantial increased SCFA levels across the whole length of the colon. Conclusion The synbiotic supplementation with B. coagulans and GBRS ameliorated the overall inflammatory status of the experimental IBD model via synergistic functioning. This supports researching its application in mitigating inflammation in human IBD.

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“…A change in gut homeostasis is associated with the onset of various severe pathological conditions, including inflammatory bowel disease (IBD) (64), a chronic relapsing inflammatory condition comprised of two clinically and morphologically different entities: Ulcerative colitis and Crohn's disease. Although the etiology of IBD is unknown, the predominant hypothesis suggests that inflammation results from a sustained immune response towards altered or pathogenic microbiota within a genetically susceptible host (65).…”

Section: Human Microbiota In Health and Diseasesmentioning

confidence: 99%

Novel perspectives on the role of the human microbiota in regenerative medicine and surgery

et al. 2016

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Plastic surgery is transitioning from a fine craftsmanship to a regenerative science. In wound healing, the role of microorganisms is no longer considered to be just counteracting, but also promoting. Furthermore, host-microbe interactions are essential for numerous aspects of normal mammalian physiology, from metabolic activity to immune homeostasis. Each area of the human body hosts a unique microbial community, and the composition of microbiota is dependent on the host, age and the anatomical area, and it changes according to the characteristics of the microenvironment. Every squared centimeter of skin contains ~1 billion bacteria. The majority of microorganisms of the skin are commensal or temporary passing members. Skin flora mechanisms interacting or influencing the human physical skin barrier are not well defined. Resident skin bacteria provide the first line of defence against potentially dangerous pathogens and produce small molecules that influence their microbial neighbours. Furthermore, the microbiota activates and assists innate immunity and influences adaptive immunity. Various types of immune and non-immune cells contribute to wound healing. The proliferative phase of wound healing is inversely proportional to the extent of the post-traumatic inflammatory reaction. Topical bacterial lipopolysaccharide application markedly affects wound healing by accelerating the resolution of inflammation, increasing macrophage infiltration, enhancing collagen synthesis and altering the secretion of mediators involved in skin regeneration. Various studies have investigated the biological contents of thermal spring waters, and their anti-inflammatory and immune protective roles. In addition, the regenerative properties of thermal spring waters were analysed in an experimental animal wound model. The areas treated with thermal water healed faster than the areas treated with conventional dressings, and exhibited a collagen and elastic fiber network comparable with the normal skin. Thus, the microbial environment may be considered as a potential tool in regenerative medicine and surgery.

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Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients

Cited by 61 publications

References 178 publications

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases

Novel perspectives on the role of the human microbiota in regenerative medicine and surgery

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