Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol

El-Deeb, Omnia Safwat; El‐Esawy, Rasha Osama; Alshenawy, Hanan AlSaeid; Ghanem, Heba Bassiony

doi:10.1080/13510002.2022.2046425

Cited by 6 publications

(2 citation statements)

References 51 publications

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“…They appear to act by modulating the expression of chemokines, their receptors and tight junction proteins, as well as restoring gut microbiota composition and normalizing disturbances in the oxidative balance associated with inflammation of colon mucosa and submucosa [ 134 , 135 , 136 , 137 ]. Additionally, β-glucans may alleviate mitochondrial dysfunction in colitis [ 138 ]. In addition, 1,6-β-glucan and 1,3-β-glucan may downregulate autoimmune inflammation occurring in IBD [ 139 ].…”

Section: Hemicelluloses As Compounds With Therapeutic Potential Again...mentioning

confidence: 99%

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Caban

Lewandowska

2023

Molecules

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Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are difficult to cure, and available treatment is associated with troubling side effects. In addition, current therapies have limited efficacy and are characterized by high costs, and a large segment of the IBD and CRC patients are refractive to the treatment. Moreover, presently used anti-IBD therapies in the clinics are primarily aimed on the symptomatic control. That is why new agents with therapeutic potential against IBD and CRC are required. Currently, polyphenols have received great attention in the pharmaceutical industry and in medicine due to their health-promoting properties. They may exert anti-inflammatory, anti-oxidative, and anti-cancer activity, via inhibiting production of pro-inflammatory cytokines and enzymes or factors associated with carcinogenesis (e.g., matrix metalloproteinases, vascular endothelial growth factor), suggesting they may have therapeutic potential against IBD and CRC. However, their use is limited under both processing conditions or gastrointestinal interactions, reducing their stability and hence their bioaccessibility and bioavailability. Therefore, there is a need for more effective carriers that could be used for encapsulation of polyphenolic compounds. In recent years, natural polysaccharides have been proposed for creating carriers used in the synthesis of polyphenol encapsulates. Among these, hemicelluloses are particularly noteworthy, being characterized by good biocompatibility, biodegradation, low immunogenicity, and pro-health activity. They may also demonstrate synergy with the polyphenol payload. This review discusses the utility and potential of hemicellulose-based encapsulations of polyphenols as support for treatment of IBD and CRC.

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Section: Hemicelluloses As Compounds With Therapeutic Potential Again...mentioning

confidence: 99%

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Caban

Lewandowska

2023

Molecules

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“…SCFA are partly generated by fermentation of β-glucans. In two different studies by El-Deeb et al, the oxazolone-induced colitis rat model was treated with β-glucans [87,88]. In both studies, the increased production of short-chain fatty acids was accompanied by a counteracting effect of oxazolone regarding mitochondrial parameters like ATP, citrate synthase activity, mitochondrial membrane potential and mitochondrial ROS.…”

Section: Role Of Mitochondria In Gut-microbiota Axismentioning

confidence: 99%

Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review

Sánchez-Quintero,

Rodríguez-Díaz,

Rodríguez-González

et al. 2023

IJMS

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Mitochondria are key cellular organelles whose main function is maintaining cell bioenergetics by producing ATP through oxidative phosphorylation. However, mitochondria are involved in a much higher number of cellular processes. Mitochondria are the home of key metabolic pathways like the tricarboxylic acid cycle and β-oxidation of fatty acids, as well as biosynthetic pathways of key products like nucleotides and amino acids, the control of the redox balance of the cell and detoxifying the cell from H2S and NH3. This plethora of critical functions within the cell is the reason mitochondrial function is involved in several complex disorders (apart from pure mitochondrial disorders), among them inflammatory bowel diseases (IBD). IBD are a group of chronic, inflammatory disorders of the gut, mainly composed of ulcerative colitis and Crohn’s disease. In this review, we present the current knowledge regarding the impact of mitochondrial dysfunction in the context of IBD. The role of mitochondria in both intestinal mucosa and immune cell populations are discussed, as well as the role of mitochondrial function in mechanisms like mucosal repair, the microbiota– and brain–gut axes and the development of colitis-associated colorectal cancer.

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