Modulating immunometabolism in transition dairy cows: the role of inflammatory lipid mediators

Immunometabolism in animal production: building efficiency from health

“…The understanding of the lipid metabolism during transition lead to the development of nutritional strategies capable of reducing inflammation through supplementation with immunomodulators such as omega-3 fatty acids or conjugated linoleic acid. Another strategy proposed by Zachut et al (2022) is the supplementation of rumen-protected niacin, which is involved in the inhibition of lipolysis, reducing the risk of immunometabolism dysfunction, also supporting the idea that reducing adipose tissue mobilization may reduce inflammation.…”

“…In the same line, Zachut et al (2022) introduce the role of lipid mediators as immunomodulators, affecting inflammation during transition in dairy cows and the possibility of using these molecules to manipulate the metabolism in order to improve animal health and productivity. Also, the authors state the importance of adipose tissue not as an energy store but as an important endocrine tissue that regulates immune activation and inflammation response.…”

Maternal supplementation with n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows

“…Supplementation with n-3 FAs can also modulate the activation of the endocannabinoid system (ECS) [ 24 , 25 ] by reducing the omega-6 (n-6) FAs to the n-3 FA ratio in the diet [ 26 ]. The ECS, which consists of the endocannabinoid ligands, cannabinoid receptors, and enzymes that synthesize and degrade the endocannabinoids, is involved in regulating energy metabolism and immune function [ 27 ].…”