Modulating OCA2 Expression as a Promising Approach to Enhance Skin Brightness and Reduce Dark Spots
Eunbyul Cho,
Kyong Eun Hyung,
Yun-Ho Choi
et al.
Abstract:The oculocutaneous albinism II (OCA2) gene encodes a melanosomal transmembrane protein involved in melanogenesis. Recent genome-wide association studies have identified several single nucleotide polymorphisms within OCA2 genes that are involved in skin pigmentation. Nevertheless, there have been no attempts to modulate this gene to improve skin discoloration. Accordingly, our aim was to identify compounds that can reduce OCA2 expression and to develop a formula that can improve skin brightness and reduce hyper… Show more
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