Modulation and detection of single neuron activity using spin transfer nano-oscillators

Algarin, J. M.; Ramaswamy, Bharath; Venuti, Lucy; Swierzbinski, Matthew E.; Villar, Pablo S.; Chen, Yujin; Weinberg, I.; Herberholz, Jens; Araneda, Ricardo C.; Shapiro, Benjamin; Waks, Edo

doi:10.1117/12.2274462

Cited by 1 publication

(2 citation statements)

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“…Work needs to be done (e.g., with template-guided synthesis) on freeing the spintronic devices from substrates for deployment as a contrast agent. The spintronic particles can be used in a reverse mode for stimulation (with radio-frequency energy converted to low-frequency currents) again with the possibility of localization with applied magnetic gradients [35].…”

Section: Readout With Spintronic Particlesmentioning

confidence: 99%

“…As discussed above, spintronic particles have been used to convert low-frequency electrical currents into high-frequency radio-frequency emissions. Our group successfully reversed this process, to convert applied radio-frequency (RF) radiation into low-frequency electrical currents that were able to affect the firing frequency of a single neuron (Figure 8) [35]. An attractive potential application of this technology is that the efficiency of conversion of the RF radiation exhibits frequency dependence that is also a function of the ambient magnetic field.…”

Section: Spintronic Particlesmentioning

confidence: 99%

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Image-guided Placement of Magnetic Neuroparticles as a Potential High-Resolution Brain-Machine Interface

Weinberg¹,

Mair²,

Jafari³

et al. 2018

Evolving BCI Therapy - Engaging Brain State Dynamics

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We are developing methods of noninvasively delivering magnetic neuroparticles™ via intranasal administration followed by image-guided magnetic propulsion to selected locations in the brain. Once placed, the particles can activate neurons via vibrational motion or magnetoelectric stimulation. Similar particles might be used to read out neuronal electrical pulses via spintronic or liquid-crystal magnetic interactions, for fast bidirectional brain-machine interface. We have shown that particles containing liquid crystals can be read out with magnetic resonance imaging (MRI) using embedded magnetic nanoparticles and that the signal is visible even for voltages comparable to physiological characteristics. Such particles can be moved within the brain (e.g., across midline) without causing changes to neurological firing.

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Section: Readout With Spintronic Particlesmentioning

confidence: 99%

Section: Spintronic Particlesmentioning

confidence: 99%