Modulation of a number of genes on personality traits in a sample of healthy subjects

Calati, Raffaella; Signorelli, Maria Salvina; Gressier, Florence; Bianchini, O.; Porcelli, Stefano; Comings, David E.; Girolamo, Giovanni de; Aguglia, Eugenio; MacMurray, James P.; Serretti, Alessandro

doi:10.1016/j.neulet.2014.02.001

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…As previously mentioned, rearing conditions are thought to explain, at least partially, the variability in social behaviour observed in healthy subjects (Hampton et al, 2016), likely as a result of a gene x environment interaction (e.g. (Calati et al, 2014;Lange et al, 2017b;Singer et al, 2017)). In other words, genetic variants and early life events jointly modulate the resilience/vulnerability of this inter-play in the specific subject (e.g.…”

Section: Genetic Variantsmentioning

confidence: 99%

Social brain, social dysfunction and social withdrawal

Porcelli

Wee

Werff

et al. 2019

Neuroscience & Biobehavioral Reviews

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Section: Genetic Variantsmentioning

confidence: 99%

Social brain, social dysfunction and social withdrawal

Porcelli

Wee

Werff

et al. 2019

Neuroscience & Biobehavioral Reviews

Self Cite

280

183

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“…In addition, there is increase evidence of the association between the 5-HTT and DRD2/DRD4 polymorphisms with character dimensions which, according to Cloninger's Theory, are acquired during the development through socio-cultural learning and not as genetically determined as the temperament dimensions (Cloninger et al 1994). Studies from different cultural populations reported that healthy subjects carriers of the short allele within the 5-HTT showed lower scores in all the Cloninger's character dimensions, including Self-Transcendence (Ham et al 2004), Self-Directedness (Gonda et al 2009;Saiz et al 2010;Calati et al 2014) and Cooperativeness (Pełka-Wysiecka et al 2012). Similarly, for the DRD2 polymorphism, Tsuchimine et al (2012) found that the less frequent allele was associated with significant lower scores in the Self-Directedness scale (Table 1).…”

mentioning

confidence: 91%

The association between the serotonin and dopamine neurotransmitters and personality traits

Delvecchio

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Figure and up to ten references). Paolo Brambilla, Section EditorThe association between the serotonin and dopamine neurotransmitters and personality traits Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

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“…Moreover, several genetic studies in humans have shown relationships between human character traits and the serotonergic system [ 13 , 14 , 15 , 16 ]. Notably, these studies reported significant associations between self-directedness and various serotonin (5-hydroxytryptamine, 5-HT) genes, including primarily 5-HT transporter (5-HTT) or 5-HT 2A receptor (5-HT2AR) genes.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Character Traits and In Vivo Cerebral Serotonin Transporter Availability in Healthy Subjects: A High-Resolution PET Study with C-11 DASB

Kim

Lee

et al. 2023

Pharmaceuticals

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To elucidate the potential roles of serotonergic activity in human character traits (i.e., self-directedness, cooperativeness, and self-transcendence), we investigated the relationship between these character traits and serotonin transporter (5-HTT) in healthy subjects. Twenty-four participants underwent High-Resolution Research Tomograph–positron emission tomography scans with [11C]DASB. To quantify 5-HTT availability, binding potential (BPND) of [11C]DASB was obtained using the simplified reference tissue model. The Temperament and Character Inventory was used to assess subjects’ levels of three character traits. There were no significant correlations between the three character traits. Self-directedness was significantly positively correlated with [11C]DASB BPND in the left hippocampus, left middle occipital gyrus, bilateral superior parietal gyrus, left inferior parietal gyrus, left middle temporal gyrus (MTG), and left inferior temporal gyrus (ITG). Cooperativeness was significantly negatively correlated with [11C]DASB BPND in the median raphe nucleus. Self-transcendence was significantly negatively correlated with [11C]DASB BPND in the right MTG and right ITG. Our results show significant correlations between the three character traits and 5-HTT availability in specific brain regions. In particular, self-directedness was significantly positively correlated with 5-HTT availability, suggesting that a goal-oriented, self-confident, and resourceful character may be related to higher serotonergic neurotransmission.

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Modulation of a number of genes on personality traits in a sample of healthy subjects

Cited by 6 publications

References 44 publications

Social brain, social dysfunction and social withdrawal

Social brain, social dysfunction and social withdrawal

The association between the serotonin and dopamine neurotransmitters and personality traits

The Relationship between Character Traits and In Vivo Cerebral Serotonin Transporter Availability in Healthy Subjects: A High-Resolution PET Study with C-11 DASB

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