Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats

Saad, Mohamed I.; Kamel, Maher A.; Hanafi, Mervat Y.

doi:10.1155/2015/138134

Cited by 38 publications

(32 citation statements)

References 25 publications

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“…Our study results elucidated that sitagliptin and saxagliptin improve lipid status in T2DM rats, via significant reduction of TCH, LDL and TGL (Figure 1). In line with these results are also the results of other research groups (35,36). Possible explanation for beneficial lipid effects of DPP4 inhibitors may be connected to its stimulating effect on the activated proteine-kinase pathway, which leads to increase in glucose and lipid catabolism (37).…”

Section: Discussionsupporting

confidence: 80%

The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

Bolevich

Draginić

Andjić

et al. 2019

Serbian Journal of Experimental and Clinical Research

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The aim of the present study was to examine, evaluate and compare the effects of administered dipeptidyl peptidase-4 (DPP4) inhibitors saxagliptin and sitagliptin on lipid status parameters and blood pressure in rats with streptozotocine induced diabetes mellitus type 2. Forty-eight Wistar albino rats were divided randomly into 4 groups: 1. group I: control healthy group; 2. group II: rats with diabetes mellitus type 2; 3. group III: rats with diabetes mellitus type 2+ treated with 0.6 mg/kg of sitagliptin; 4. group IV: rats with diabetes mellitus type 2 treated with 0.45 mg/kg of saxagliptin. The rats from experimental groups were fed with a high-fat diet for 4 weeks and after 6–8 h of starvation received one dose of streptozotocin (STZ) intraperitoneally (25 mg/kg body weight) to induce type 2 diabetes mellitus (T2DM). Animals with fasting glucose above 7 mmol/L and insulin over 6 mmol/L were included in the study as rats with T2DM. Upon completion of the experiments, the blood was collected from the anesthetized animals and serum triglyceride (TG), total cholesterol (TCH), high density lipoprotein (HDL), and low density lipoprotein (LDL) were measured using spectrophotometry and commercial kits. At the beginning of the study and the day before sacrificing animals, the blood pressure and heart rate were measured by a tail-cuff noninvasive method. DPP4 inhibitors, as glucagon-like peptide-1 (GLP-1) agonists, were associated with modest reductions in DBP, LDL-C, TCH, and TGL and significant improvement in HDL, SBP and HR.

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Section: Discussionsupporting

confidence: 80%

The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

Bolevich

Draginić

Andjić

et al. 2019

Serbian Journal of Experimental and Clinical Research

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“…Studies have shown that the action of adiponectin is closely related to its effect on the sensitivity to insulin in diabetic animals (Saad et al . ) and plays an important role in inflammation (Cao ). However, its exact influence or its relationship with the adipocytokines, such as vaspin and omentin, in obese individuals with type 2 diabetes is still unclear and further research is needed to clarify these facts.…”

Section: Discussionmentioning

confidence: 99%

Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats

Castro

Silva

Buffo

et al. 2017

Int J Experimental Path

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Vaspin and omentin are adipose tissue adipokines that have often been related to obesity and its comorbidities. The aim of this study was to investigate the behaviour of serum omentin and vaspin in models of type 2 diabetes. To do this, Wistar rats (~200 g) were randomly divided into two groups: a non-diabetic group (n = 6) and a diabetic group fed on a high-fat diet (n = 6) and a low dose of streptozotocin (Sigma ). All procedures were approved by the Brazilian Ethics Committee. Body weight (BW) and food intake were recorded daily. Tail blood glucose levels were assessed at the end of the diabetes induction period. The insulin tolerance test (ITT) was performed after the diabetes induction period (7 weeks). The serum and tissues (liver, pancreas, and retroperitoneal (RET), epididymal (EPI) and visceral (VIS) white adipose tissues) were immediately removed and weighed. Analyses of levels of insulin, omentin, vaspin, adiponectin and inflammatory cytokines IL-6, IL-8 (CXCL8), TNF-α and C-reactive protein (CRP) in serum were performed using the enzyme-linked immunosorbent assay (ELISA). Our results showed that IL-8 and CRP serum levels in the diabetic group were significantly higher than in the non-diabetic group. Vaspin and adiponectin values were lower for the diabetic group than for the non-diabetic group. Omentin, IL-6 and TNF-α values did not differ between the groups. Our results showed that both the metabolism of the adipose tissue and the secretion of adipokines may be affected in diabetic rats. Omentin showed no difference between the groups, although the vaspin values decreased in the diabetic group.

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“…[72] In the current study, insulin-resistant diabetic rats showed a significant decrease in serum ADP along with an increase in LEP levels with respect to normal rats; this is in accordance with the results of the previous studies. [73,74] The inverse association between ADP and IR may reflect the suppression of ADP production by compensatory hyperinsulinemia. [75] Moreover, serum ADP levels were lowered in obesity although adipose was the only tissue responsible for its synthesis, suggesting negative feedback on its production.…”

Section: Glut-2 Gene Expressionmentioning

confidence: 99%

Lansoprazole enhances the antidiabetic effect of dapagliflozin in fortified diet‐fed streptozotocin‐treated diabetic rats

Gamil

Fattah

Ahmed

et al. 2020

J Biochem & Molecular Tox

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Dapagliflozin (DAPA) is used for treating type 2 diabetes, whereas lansoprazole (LPZ) is used as a traditional antiulcer drug. The present study investigated the possible antidiabetic effects of LPZ on fortified diet‐fed streptozotocin (FDF/STZ)‐induced insulin‐resistant diabetic rats. On the basis of the current results, it can be concluded that LPZ could be used as an add‐on drug along with the conventional treatment for T2D as it showed beneficial effects in the current experimental model of insulin resistance.

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Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats

Cited by 38 publications

References 25 publications

The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats

Lansoprazole enhances the antidiabetic effect of dapagliflozin in fortified diet‐fed streptozotocin‐treated diabetic rats

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