Modulation of alcohol and nicotine responses through the endogenous opioid system

Drews, Eva; Zimmer, Andreas

doi:10.1016/j.pneurobio.2009.09.004

Cited by 56 publications

(63 citation statements)

References 186 publications

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“…Addictive substances, including nicotine and alcohol, are believed to exert their rewarding effects by stimulating release of nucleus accumbens DA and opioid peptides (Gianoulakis, 2004;Soderpalm, et al, 2000). Relatedly, chronic substance use is associated with hypoactivity in the mesolimbic DA pathway (Altmann et al, 1996;Volkow et al, 2004) and the opioid system (Drews and Zimmer, 2010). It therefore follows that during acute abstinence, when neurochemical activity is not being artificially enhanced by substance use, smokers are likely to show reduced capacity for salience attribution and that this should manifest in motivational and emotional blunting.…”

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confidence: 99%

Effects of nicotine and alcohol on affective responses to emotionally toned film clips

Dawkins

Powell

2011

Psychopharmacology

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2Rationale: Smoking abstinence can result in decreased affective reactions to positively valenced stimuli and this can be reversed via smoking. Given their shared ability to trigger nucleus accumbens dopamine release, a priming dose of alcohol may likewise augment positive affective responses during abstinence. AbstractObjectives: To replicate our previous finding that compared to satiation, abstinence from smoking will be associated with decreased 'happiness' responses to positively valenced film clips (study 1); and to explore whether a priming dose of alcohol can substitute for nicotine by concomitantly enhancing such responses (study 2). In both studies 'sadness' responses to negatively valenced clips were also included.Methods: 32 and 77 smokers respectively in studies 1 and 2 were randomly allocated to abstain from smoking for 10 hours (abstinent smokers) or smoke as usual (satiated smokers).Participants then rated the extent to which they felt a list of emotions in response to each of 16 film clips. In study 2, participants were additionally allocated to an alcohol manipulation in which they received either alcohol or placebo.Results: In Study 1, nicotine administration increased abstinent smokers' ratings of happiness and sadness to the corresponding film clips. In Study 2, nicotine and alcohol both enhanced positive reactivity to happy clips, and their effects were not additive. Alcohol but not nicotine likewise enhanced sadness responses to sad clips. Conclusions:Abstinence from smoking can result in blunting of affective responses to positively toned stimuli, an effect that can be ameliorated by both nicotine and alcohol. The impact of nicotine on negative reactivity appears to be less robust.3

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confidence: 99%

Effects of nicotine and alcohol on affective responses to emotionally toned film clips

Dawkins

Powell

2011

Psychopharmacology

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“…Анализируя сведения о табакокурении и ТЗ, неко-торые авторы, однако, не приводят точные показа-тели распространенности никотиновой зависимо-сти с учетом пола и возраста, хотя и говорят о более частых случаях ТЗ и АЗ у мужчин и курильщиков с длительностью табакокурения 25 лет и более [7]. В некоторых работах [2,7,[15][16][17] констатируется б`льшая распространенность табакокурения и ТЗ среди больных АЗ, которая может превышать пока-затели в общей популяции в 2-10 раз. Только в од-ной работе из Японии ТЗ среди больных алкоголиз-мом оказалась ниже (22%), чем среди здоровых (54,4%) [10].…”

Section: результаты и обсуждениеunclassified

“…Боль-шую роль при этом также играет курение матери во время беременности, ранний возраст курящего к периоду начала потребления им алкоголя [17]. Наследственная отягощенность у пациентов с болезнями зависимости колеблется от 40 до 80% [15,16]. Эти показатели согласуются с нашими данны-ми.…”

Section: результаты и обсуждениеunclassified

“…В зарубежных публикациях описываются рас-пространенность ТЗ у больных с АЗ, их этиология, клиника, нейробиологические, нейрокогнитивные и генетические аспекты, синдром отмены, влечения в процессе лечения и реабилитации, подходы к ле-чению ТЗ [4][5][6][7][8][9][10][11][12][15][16][17][18]. Установлено, что хрони-ческая никотиновая интоксикация действует не только на никотиновые рецепторы в мозге, но также и на структуры, которые вызывают аффинитет к ни-котину.…”

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“…Острая интоксикация никотином или ал-коголем ведет к развитию реакции опиоидных пеп-тидов в специфических отделах мозга, которые вы-зывают активацию соответствующих рецепторов. При хронической интоксикации происходят адап-тивные изменения, вызывающие гомеостатическую или (ауто)аллопластическую адаптацию мозга [15].…”

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A clinical and psychological study of tobacco dependence in patients with alcoholism

Голенков

Kozlov

Сапожников

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Frequency of and Factors Associated With Nonmedical Opioid Use Behavior Among Patients With Cancer Receiving Opioids for Cancer Pain

et al. 2021

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IMPORTANCEOne of the main aims of research on nonmedical opioid use (NMOU) is to reduce the frequency of NMOU behaviors through interventions such as universal screening, reduced opioid exposure, and more intense follow-up of patients with elevated risk. The absence of data on the frequency of NMOU behavior is the major barrier to conducting research on NMOU.OBJECTIVE To determine the overall frequency of and the independent predictors for NMOU behavior. DESIGN, SETTING, AND PARTICIPANTSIn this prognostic study, 3615 patients with cancer were referred to the supportive care center at MD Anderson Cancer Center from March 18, 2016, to June 6, 2018. Patients were eligible for inclusion if they had cancer and were taking opioids for cancer pain for at least 1 week. Patients were excluded if they had no follow-up within 3 months of initial consultation, did not complete the appropriate questionnaire, or did not have scheduled opioid treatments. After exclusion, a total of 1554 consecutive patients were assessed for NMOU behavior using established diagnostic criteria. All patients were assessed using the Edmonton Symptom Assessment Scale, the Screener and Opioid Assessment for Patients with Pain (SOAPP), and the Cut Down, Annoyed, Guilty, Eye Opener-Adapted to Include Drugs (CAGE-AID) survey. Data were analyzed from January 6 to September 25, 2020.RESULTS A total of 1554 patients (median [interquartile range (IQR)] age, 61 [IQR,[52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] years; 816 women [52.5%]; 1124 White patients [72.3%]) were evaluable for the study, and 299 patients (19.2%) had 1 or more NMOU behaviors. The median (IQR) number of NMOU behaviors per patient was 1 (IQR, 1-3). A total of 576 of 745 NMOU behaviors (77%) occurred by the first 2 follow-up visits. The most frequent NMOU behavior was unscheduled clinic visits for inappropriate refills (218 of 745 [29%]). Eighty-eight of 299 patients (29.4%) scored 7 or higher on SOAPP, and 48 (16.6%) scored at least 2 out of 4 points on the CAGE-AID survey. Results from the multivariate model suggest that marital status (single, hazard ratio [HR], 1.58; 95% CI, 1.15-2.18; P = .005; divorced, HR, 1.43; 95% CI, 1.01-2.03; P = .04), SOAPP score (positive vs negative, HR, 1.35; 95% CI, 1.04-1.74; P = .02), morphine equivalent daily dose (MEDD) (HR, 1.003; 95% CI, 1.002-1.004; P < .001), and Edmonton Symptom Assessment Scale pain level (HR, 1.11; 95% CI, 1.06-1.16; P < .001) were independently associated with the presence of NMOU behavior. In recursive partition analysis, single marital status, MEDD greater than 50 mg, and SOAPP scores greater than 7 were associated with a higher risk (56%) for the presence of NMOU behavior.CONCLUSIONS AND RELEVANCE This prognostic study of patients with cancer taking opioids for cancer pain found that 19% of patients developed NMOU behavior within a median duration of 8 weeks after initial supportive care clinic consultation. Marital status (single or divorced), SOAPP score greater than 7, higher levels of pain se...

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Modulation of alcohol and nicotine responses through the endogenous opioid system

Cited by 56 publications

References 186 publications

Effects of nicotine and alcohol on affective responses to emotionally toned film clips

Effects of nicotine and alcohol on affective responses to emotionally toned film clips

A clinical and psychological study of tobacco dependence in patients with alcoholism

Frequency of and Factors Associated With Nonmedical Opioid Use Behavior Among Patients With Cancer Receiving Opioids for Cancer Pain

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