Modulation of antibiotic effects on microbial communities by resource competition

Newton, Daniel Philip; Ho, Po-Yi; Huang, Kerwyn Casey

doi:10.1038/s41467-023-37895-x

Cited by 12 publications

(4 citation statements)

References 44 publications

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“…MBGS showed resilience to single antibiotic at concentrations up to 10 mg/L, implying that the combined effects and long-term exposure of antibiotic mixtures, even at relatively low concentrations, could lead to stronger inhibition of key bacterial/microalgal metabolic functions. This phenomenon can be attributed to the distinct and selective organelles, functions, or metabolic pathways targeted by each class of antibiotics in bacteria or microalgae. , …”

Section: Resultsmentioning

confidence: 99%

Unraveling the Role of Microalgae in Mitigating Antibiotics and Antibiotic Resistance Genes in Photogranules Treating Antibiotic Wastewater

Kiki,

Qin,

Liu

et al. 2023

Environ. Sci. Technol.

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Harnessing the potential of specific antibiotic-degrading microalgal strains to optimize microalgal-bacterial granular sludge (MBGS) technology for sustainable antibiotic wastewater treatment and antibiotic resistance genes (ARGs) mitigation is currently limited. This article examined the performance of bacterial granular sludge (BGS) and MBGS (of Haematococcus pluvialis, an antibiotic-degrading microalga) systems in terms of stability, nutrient and antibiotic removal, and fate of ARGs and mobile genetic elements (MGEs) under multiclass antibiotic loads. The systems exhibited excellent performance under none and 50 μg/L mixed antibiotics and a decrease in performance at a higher concentration. The MBGS showed superior potential, higher nutrient removal, 53.9 mg/L/day higher chemical oxygen demand (COD) removal, and 5.2−8.2% improved antibiotic removal, notably for refractory antibiotics, and the system removal capacity was predicted. Metagenomic analysis revealed lower levels of ARGs and MGEs in effluent and biomass of MBGS compared to the BGS bioreactor. Particle association niche and projection pursuit regression models indicated that microalgae in MBGS may limit gene transfers among biomass and effluent, impeding ARG dissemination. Moreover, a discrepancy was found in the bacterial antibiotic-degrading biomarkers of BGS and MBGS systems due to the microalgal effect on the microcommunity. Altogether, these findings deepened our understanding of the microalgae's value in the MBGS system for antibiotic remediation and ARG propagation control.

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Section: Resultsmentioning

confidence: 99%

Unraveling the Role of Microalgae in Mitigating Antibiotics and Antibiotic Resistance Genes in Photogranules Treating Antibiotic Wastewater

Kiki,

Qin,

Liu

et al. 2023

Environ. Sci. Technol.

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“…Igler, Rolff, and Regoes [11] successfully implement bacteriostatic and bactericidal modes of action, and also speculate that bacteriostatic drugs may limit the evolution of AMR, however they do not investigate this, instead focusing on the effects of varying the pharmacokinetic model used. Newton, Ho, and Huang [27] also implement the difference between bactericidal and bacteriostatic drugs appropriately in their recent model, but they explore community dynamics among competing species, without considering the evolution of resistance.…”

Section: Discussionmentioning

confidence: 99%

Drug mode of action and resource constraints modulate antimicrobial resistance evolution

Delaney,

Letten,

Engelstädter

2023

Preprint

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One of the key characteristics of an antibiotic drug is its mode of action: bacteriostatic or bactericidal. The effect of drug mode of action on the evolution of resistance has been surprisingly underinvestigated to date. We present a theoretical model comparing the efficacy of bacteriostatic and bactericidal drugs, and drugs of intermediate type, at preventing the evolutionary rescue of an initially susceptible bacterial population in a patient. Our results suggest that in resource-abundant environments bacteriostatic drugs are best, as they constrain cell divisions and thus cause fewer resistance mutations to occur. When multiple drugs are employed, using one bacteriostatic and one bactericidal drug is usually optimal, because the cell division rate cannot fall below zero, so there are diminishing returns to bacteriostatic activity from two drugs. We also provide a web-based simulation engine for other researchers to intuitively explore related dynamics without requiring programming expertise.

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“…Ecological theory 55,56 suggests that the low levels of commensal colonization in the subjects with lasting antibiotic responses could be driven by the functional redundancy of the gut microbiome.…”

Section: Commensal Strains Abruptly Colonize Subjects With Lasting An...mentioning

confidence: 99%

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

Xue,

Walton,

Goldman

et al. 2023

Preprint

Self Cite

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Humans constantly encounter new microbes, but few become long-term residents of the adult gut microbiome. Classical theories predict that colonization is determined by the availability of open niches, but it remains unclear whether other ecological barriers limit commensal colonization in natural settings. To disentangle these effects, we used a controlled perturbation with the antibiotic ciprofloxacin to investigate the dynamics of gut microbiome transmission in 22 households of healthy, cohabiting adults. Colonization was rare in three-quarters of antibiotic-taking subjects, whose resident strains rapidly recovered in the week after antibiotics ended. In contrast, the remaining subjects exhibited lasting responses to antibiotics, with extensive species losses and transient expansions of potential opportunistic pathogens. These subjects experienced elevated rates of commensal colonization, but only after long delays: many new colonizers underwent sudden, correlated expansions months after the antibiotic perturbation. Furthermore, strains that had previously transmitted between cohabiting partners rarely recolonized after antibiotic disruptions, showing that colonization displays substantial historical contingency. This work demonstrates that there remain substantial ecological barriers to colonization even after major microbiome disruptions, suggesting that dispersal interactions and priority effects limit the pace of community change.

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Modulation of antibiotic effects on microbial communities by resource competition

Cited by 12 publications

References 44 publications

Unraveling the Role of Microalgae in Mitigating Antibiotics and Antibiotic Resistance Genes in Photogranules Treating Antibiotic Wastewater

Unraveling the Role of Microalgae in Mitigating Antibiotics and Antibiotic Resistance Genes in Photogranules Treating Antibiotic Wastewater

Drug mode of action and resource constraints modulate antimicrobial resistance evolution

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

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