Modulation of antibody-forming cell and mitogen-driven lymphoproliferative responses by dietary nucleotides in mice

Navarro, J.; Ruiz‐Bravo, Alfonso; Jiménez-Valera, Marı́a; Gil, Ángel

doi:10.1016/s0165-2478(96)02624-7

Cited by 42 publications

(31 citation statements)

References 10 publications

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“…Serum immunoglobulins are major components of the humoral immune system and IgM is the main immunoglobulin present in fish [28]. It has been suggested that nucleotides exert their greatest impact on the immune system by modulating immunoglobulin [29]. Low et al [30] discovered that dietary nucleotides enhanced expression of IgM in certain tissues of turbot.…”

Section: Discussionmentioning

confidence: 99%

Dietary administration of nucleotides to enhance growth, humoral immune responses, and disease resistance of the rainbow trout (Oncorhynchus mykiss) fingerlings

Tahmasebi-Kohyani

Keyvanshokooh

Nematollahi

et al. 2011

Fish & Shellfish Immunology

102

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Section: Discussionmentioning

confidence: 99%

Dietary administration of nucleotides to enhance growth, humoral immune responses, and disease resistance of the rainbow trout (Oncorhynchus mykiss) fingerlings

Tahmasebi-Kohyani

Keyvanshokooh

Nematollahi

et al. 2011

Fish & Shellfish Immunology

102

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“…More recently, our work group has reported in BALB=c mice that the addition of nucleotide mixtures to a nucleotide-free diet resulted in an increase in the response of haemolytic IgG-forming cells induced by previous immunization with sheep erythrocytes; when the diet was supplemented with single nucleotides, AMP, GMP or UMP increased the IgG response whereas CMP and IMP had no effect. GMP was the only nucleotide that increased the haemolytic IgM-forming cell response (Navarro et al, 1996).…”

Section: Modulation Of Immunoglobulin Production By Nucleotidesmentioning

confidence: 98%

“…Likewise, the use of cyclosporine as an immunosuppressor agent in mice had a synergic effect when combined with a nucleotide-free diet, leading to a higher period of allograft survival (Kulkarni et al, 1989). However, no differences were seen when mice were inoculated with a fibrosarcoma or the LSTRA syngenic lymphoma, which is highly agressive (Navarro et al, 1996). Natural killer (NK) cells are one of the main populations involved in the immune response against transformed cells.…”

Section: Nucleotide Modulation Of the Delayed Hypersensitivity And Almentioning

confidence: 99%

Modulation of the immune response mediated by dietary nucleotides

2002

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Dietary nucleotides have been reportedly beneficial, especially for infants, since they positively influence lipid metabolism, immunity, and tissue growth, development and repair. Rapidly proliferating tissues, such as the immune system or the intestine are not able to fulfil the needs of cell nucleotides exclusively by de novo synthesis and they preferentially utilize the salvage pathway recovering nucleosides and nucleobases from blood and diet. In the present review we describe the modulatory effect of dietary nucleotides on the immune system together with some of their effects on gut-associated lymphoid tissue. Dietary nucleotides influence lymphocyte maturation, activation and proliferation. Likewise, they affect the lymphocyte subset populations in both the small intestine and blood. Moreover, they are involved in enhancing macrophage phagocytosis and delayed hypersensitivity as well as allograft and tumour responses. In addition, they contribute to the immunoglobulin response in early life, having a positive effect on infection. In fact the incidence and duration of acute diarrhoea is lower in infants fed supplemented-nucleotide formulas. The molecular mechanisms by which dietary nucleotides modulate the immune system are practically unknown. Dietary nucleotides have been shown to enhance the production and the genetic expression of IL-6 and IL-8 by foetal small intestinal explants. Dietary nucleotides may influence protein biosynthesis as well as signal membrane transduction mediated by the interaction of exogenous nucleosides and their receptors may also contribute to modulate the expression of a number of genes, some of which can directly affect the levels of intestinal cytokines.

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“…In contrast to Carver et al [26], they found no differences in NK cell numbers between these 2 groups. In studies conducted on newborn rodents, formula containing nucleotides was associated with increased levels of NK cell activity, macrophage activity, IL-2 release and IL-2 receptor expression [28,29]. Research has also shown that lactoferrin, which is concentrated in the whey component of HM; increases NK cell activity and lymphokine-dependent cytotoxic activity [30].…”

Section: Discussionmentioning

confidence: 99%

Influence of Feeding Formula and Breast Milk Fortifier on Lymphocyte Subsets in Very Low Birth Weight Premature Newborns

Tarcan

Gürakan²,

Tiker³

et al. 2004

Neonatology

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Background: It is well known that breast-feeding protects the newborn from infectious diseases. This is especially important for very low birth weight preterm infants, whose immune systems are immature. In this study we investigated how a milk fortifier and replacement formula affected lymphocyte subsets in preterm infants. Method: The study assessed the effects of different types of feeding (human milk, n = 14; fortified human milk, n = 16; formula, n = 14) on lymphocyte subsets in 44 very low birth weight preterm infants. For each baby, two consecutive blood samples were collected 7–10 days apart during the full enteral feeding period. For each sample, the percentages of CD3+ (pan-T), CD19+ (B-cell), CD4+ (T-helper), CD8+ (T-suppressor), and CD3–CD16/56+ (natural killer cell) lymphocytes were measured in a flow cytometer, and the absolute count for each subset was calculated based on the total lymphocyte count. Within each feeding group, the absolute numbers of each lymphocyte subset in the two consecutive samples were compared. Also, the mean absolute counts for each cell type were compared among the 3 groups for the first set of blood samples, and the same comparisons were made for the second set. Results: The mean number of CD3–CD16/56+ cells in the formula-fed infants was significantly lower than the corresponding means in the groups fed human milk alone and fortified human milk (p = 0.037). Conclusion: The findings suggest that babies fed formula have different lymphocyte subset compositions than those fed breast milk or fortified breast milk.

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Modulation of antibody-forming cell and mitogen-driven lymphoproliferative responses by dietary nucleotides in mice

Cited by 42 publications

References 10 publications

Dietary administration of nucleotides to enhance growth, humoral immune responses, and disease resistance of the rainbow trout (Oncorhynchus mykiss) fingerlings

Dietary administration of nucleotides to enhance growth, humoral immune responses, and disease resistance of the rainbow trout (Oncorhynchus mykiss) fingerlings

Modulation of the immune response mediated by dietary nucleotides

Influence of Feeding Formula and Breast Milk Fortifier on Lymphocyte Subsets in Very Low Birth Weight Premature Newborns

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