Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders

Pathophysiological Roles of Serotonergic System in Regulating Extrapyramidal Motor Functions

“…4) Although an early study reported that the 5-HT 6 antagonist Ro 04-6790 failed to affect haloperidol-induced catalepsy, 33) we recently demonstrated that the 5-HT 6 antagonist SB-258585 alleviated haloperidol-induced bradykinesia and catalepsy. 29,30) In addition, the EPS-potentiating action of 5-HTP was also blocked by systemic injection of SB-258585 or its microinjection into the striatum, implying that blockade of the striatal 5-HT 6 receptors is at least in part involved in alleviating antipsychotic-induced EPS (Fig. 2 and Table 1).…”

“…[28][29][30] Recent clinical studies also showed that ondansetron significantly reduced the incidence and severity of antipsychotic-induced EPS (e.g., akathisia and parkinsonism) in patients with chronic schizophrenia. 31,32) In our studies, activation of the serotonergic system by 5-hydroxytryptophan (5-HTP) significantly potentiated haloperidol-induced catalepsy and this 5-HTPpotentiated EPS was also suppressed by systemic treatments or intrastriatal microinjections of ondansetron.…”

Atypical antipsychotic properties of AD-6048, a primary metabolite of blonanserin

“…For the evaluation of bradykinesia induction, a pole-test was carried out as described previously (Ohno et al, 1994(Ohno et al, , 2008Tatara et al, 2012). Mice were placed head-upward at the top of a wooden pole (8 mm in diameter and 45 cm height), and then the time for the animal to rotate downward completely (T turn ) and descend to the floor (T total ) was measured with a maximum limit of 90 s. Bradykinesia was evaluated as the prolongation of T turn and T total values.…”

“…The catalepsy-test was carried out as described previously (Ohno et al, 2008;Tatara et al, 2012). Briefly, the forepaws of the mice were placed on a horizontal bar positioned 5 cm above the bench surface, and the time taken for the animals to show a cataleptic posture, which was defined as an immobile posture while keeping both forelimbs on the bar, was measured with a maximum limit of 60 s. AD-6048 (0.1-10 mg/kg, s.c.), HAL (0.03-3 mg/kg, s.c.) or vehicle was administered to the mice 30 min before the catalepsy-test.…”

Shu-Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint

“…Symptom relief is the goal for the treatment of PMS and it is generally acknowledged that serotonergic antidepressants, including citalopram, escitalopram, fluoxetine, sertraline and venlafaxine, are the first-line pharmacological therapies (2)(3)(4). However, these treatments are limited by their cost and the severe side effects associated with long-term medication regimens (5)(6)(7). Therefore, studies to develop novel pharmacological agents with improved therapeutic effects and fewer side effects are highly important.…”