Modulation of antiviral immunity by the ichnovirus HdIV in Spodoptera frugiperda

Visconti, Vincent; Eychenne, Magali; Darboux, Isabelle

doi:10.1016/j.molimm.2019.02.011

Cited by 13 publications

(12 citation statements)

References 74 publications

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“…Previously, we demonstrated that HdIV and JcDV infection viruses modulate two important programmed cell death pathways, autophagy and apoptosis, respectively. In particular, injection of HdIV into S. frugiperda larvae induced apoptosis in haemocytes and fat body 24 h post-infection [35], while infection of the IPLB-Ld652Y cells with JcDV activated autophagy by inhibiting the TOR pathway 4 days after infection [60]. In the present work, we found that many genes involved in positive regulation of apoptosis, such as dronc , caspase 1 , apaf1 , wengen , p rotein lifeguard 1 , innexin 2 and innexin 3 , were upregulated in the two immune tissues 72 h after infection with HdIV and JcDV ().…”

Section: Resultsmentioning

confidence: 99%

“…The viral proteins neutralize the host immune response, which promotes parasitoid survival. In particular, we previously demonstrated that HdIV infection triggers cell death by apoptosis in the fat body and haemocytes of S. frugiperda larvae, allowing elimination of important host immune tissues [35]. The growth and development rate of infected larvae is also disrupted until development of the parasite is complete [36][37][38].…”

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confidence: 99%

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Genome-wide identification of lncRNAs associated with viral infection in Spodoptera frugiperda

Robin

Legeai

Jouan

et al. 2023

Journal of General Virology

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The role of lncRNAs in immune defence has been demonstrated in many multicellular and unicellular organisms. However, investigation of the identification and characterization of long non-coding RNAs (lncRNAs) involved in the insect immune response is still limited. In this study, we used RNA sequencing (RNA-seq) to investigate the expression profiles of lncRNAs and mRNAs in the fall armyworm Spodoptera frugiperda in response to virus infection. To assess the tissue- and virus-specificity of lncRNAs, we analysed and compared their expression profiles in haemocytes and fat body of larvae infected with two entomopathogenic viruses with different lifestyles, i.e. the polydnavirus HdIV (Hyposoter didymator IchnoVirus) and the densovirus JcDV (Junonia coenia densovirus). We identified 1883 candidate lncRNAs, of which 529 showed differential expression following viral infection. Expression profiles differed considerably between samples, indicating that many differentially expressed (DE) lncRNAs showed virus- and tissue-specific expression patterns. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and target prediction analyses indicated that DE-LncRNAs were mainly enriched in metabolic process, DNA replication and repair, immune response, metabolism of insect hormone and cell adhesion. In addition, we identified three DE-lncRNAs potentially acting as microRNA host genes, suggesting that they participate in gene regulation by producing miRNAs in response to virus infection. This study provides a catalogue of lncRNAs expressed in two important immune tissues and potential insight into their roles in the antiviral defence in S. frugiperda. The results may help future in-depth functional studies to better understand the biological function of lncRNAs in interaction between viruses and the fall armyworm.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Genome-wide identification of lncRNAs associated with viral infection in Spodoptera frugiperda

Robin

Legeai

Jouan

et al. 2023

Journal of General Virology

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“…The symptoms are loss of appetite, lethargy, body sagging, softening of the integument, and a tendency to turn off color. Some viruses studied against S. frugiperda are Rhabdovirus (Sf-RV) [61]; granulovirus (SfGV ARG) type 1, 2, and 3 [62,63]; ascovirus (SfAV-1a) [64]; ichnovirus (HdIV) [65]; and the most studied, nucleopolyhedrovirus (SfMNPV) [55,66]. Undoubtedly, this strategy has shown high efficiency in the control of S. frugiperda in in vitro evaluations.…”

Section: Biological Controlmentioning

confidence: 99%

Advances in Control Strategies against Spodoptera frugiperda. A Review

et al. 2021

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The strategies for controlling the insect pest Spodoptera frugiperda have been developing over the past four decades; however, the insecticide resistance and the remarkable adaptability of this insect have hindered its success. This review first analyzes the different chemical compounds currently available and the most promising options to control S. frugiperda. Then, we analyze the metabolites obtained from plant extracts with antifeedant, repellent, insecticide, or ovicide effects that could be environmentally friendly options for developing botanical S. frugiperda insecticides. Subsequently, we analyze the biological control based on the use of bacteria, viruses, fungi, and parasitoids against this pest. Finally, the use of sex pheromones to monitor this pest is analyzed. The advances reviewed could provide a wide panorama to guide the search for new pesticidal strategies but focused on environmental sustainability against S. frugiperda.

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“…TRINITY_DN10280_c0_g1_i1_3) related to apoptosis in this study was downregulated. Apoptosis process, one of the innate antiviral responses in many host organisms, is considered to be an antiviral response [31][32][33], and down-regulation of apoptosis process is conducive to the replication and spread of viruses. Our result conflicted with the work by Guo et al [11].…”

Section: Qrt-pcr Validation Of Degsmentioning

confidence: 99%

Transcriptional Responses of Daphnis nerii Larval Midgut to Oral Infection by 2 Daphnis nerii cypovirus-23

Kuang

Cheng-hua

Zhan

et al. 2021

Preprint

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Background: Daphnis nerii cypovirus-23 (DnCPV-23) is a new type of cypovirus and has lethal effect on the oleander hawk moth, Daphnis nerii , which feeds on leave of Oleander and Catharanthus et al. After DnCPV-23 infection, the change of Daphnis nerii responses has not been reported.Methods: In order to better understand the pathogenic mechanism of DnCPV-23 infection, 3rdinstar Daphnis nerii larvae were orally infected with DnCPV-23 occlusion bodies and the transcriptional responses of the Daphnis nerii midgut were analyzed 72 h post-infection using RNA-seq.Results: The results showed that 1,979 differentially expressed Daphnis nerii transcripts in the infected midgut had been identified. KEGG analysis showed that protein digestion and absorption, Toll and Imd signaling pathway were down-regulated. Based on the result, it was possible the function of food digestion and absorption in insect midgut was impaired after virus infection. In addition, the down-regulation of the immune response may be conducive to viral immune escape. Glycerophospholipid metabolism and xenobiotics metabolism were up-regulated. These two types of pathways may affect the viral replication and xenobiotic detoxification of insect, respectively. Conclusion: These results may facilitate a better understanding of the changes in Daphnis nerii metabolism during cypovirus infection and serve as a basis for future research on the molecular mechanism of DnCPV-23 invasion.

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Modulation of antiviral immunity by the ichnovirus HdIV in Spodoptera frugiperda

Cited by 13 publications

References 74 publications

Genome-wide identification of lncRNAs associated with viral infection in Spodoptera frugiperda

Genome-wide identification of lncRNAs associated with viral infection in Spodoptera frugiperda

Advances in Control Strategies against Spodoptera frugiperda. A Review

Transcriptional Responses of Daphnis nerii Larval Midgut to Oral Infection by 2 Daphnis nerii cypovirus-23

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