2017
DOI: 10.1016/j.ajpath.2016.11.011
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Modulation of Antiviral Immunity by Heme Oxygenase-1

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Cited by 97 publications
(94 citation statements)
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“…Upregulation of HO-1 suppresses infection of several viruses, including HIV, HCV, hepatitis B virus, Ebola virus, and influenza virus (16). To evaluate whether HO-1 induction reduces hRSV infection in vitro, we pretreated the human airway epithelial cell line A549 with increasing concentrations of CoPP (an HO-1 inducer), vehicle, or SnPP (an allosteric HO-1 inhibitor) for 2 h (Fig.…”
Section: Ho-1 Induction Inhibits Hrsv Replication and Virus Particlementioning
confidence: 99%
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“…Upregulation of HO-1 suppresses infection of several viruses, including HIV, HCV, hepatitis B virus, Ebola virus, and influenza virus (16). To evaluate whether HO-1 induction reduces hRSV infection in vitro, we pretreated the human airway epithelial cell line A549 with increasing concentrations of CoPP (an HO-1 inducer), vehicle, or SnPP (an allosteric HO-1 inhibitor) for 2 h (Fig.…”
Section: Ho-1 Induction Inhibits Hrsv Replication and Virus Particlementioning
confidence: 99%
“…Heme oxygenase-1 (HO-1) is a metabolic enzyme that catalyzes the degradation of heme into carbon monoxide, biliverdin, and free iron (9). This enzyme has anti-inflammatory and antioxidant properties, which modulate host innate and adaptive immune responses (10). The immunomodulatory capacity of HO-1 has been demonstrated in several models, such as the LPS-induced acute lung inflammation in which HO-1 activation decreased the migration of polymorphonuclear leukocytes to the lung, reducing oxidative tissue damage (11).…”
mentioning
confidence: 99%
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“…MPPs such as ZnPP and SnPP influence cellular levels of heme precursors in the protoporphyrin synthetic pathway through feedback and also induce HO-1 expression and heme oxidation possibly implicating multiple sites of antiviral activity. 18,[54][55][56] Overexpression of HO-1 has been shown to directly inhibit HCV replication. 23 Consequently, in addition to NS3-4A inhibition, MPPs offer further possibilities for interactions with host cell enzymes that are likely to enhance the direct HCV antiviral actions.…”
Section: Discussionmentioning
confidence: 99%