Modulation of arachidonic acid metabolism by phenols: Relation to positions of hydroxyl groups and peroxyl radical scavenging properties

Alanko, Juha; Riutta, Asko; Muchá, I.; Vapaatalo, Heikki; Metsä‐Ketelä, T.

doi:10.1016/0891-5849(93)90505-o

Cited by 46 publications

(22 citation statements)

References 29 publications

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“…Therefore, methods have been developed for the estimation of the ''total antioxidant capacity'' and these methods have been based on the trapping of peroxyl radicals in vitro (Warner et al 1985;Darley-Usmar et al 1989;Alanko et al 1993;Ahotupa et al 1996). To estimate the effect of exercise on antioxidative functions at moderate altitude and at sea level, we measured the total antioxidant potential in serum by the TRAP method.…”

Section: Discussionmentioning

confidence: 99%

“…Since there are so many antioxidant agents, the total antioxidative defence capacity of the tissues cannot be assessed by measuring the concentrations of only a few individual antioxidants. Therefore, methods have been developed for the estimation of the ''total antioxidant capacity'' and these methods are based on the trapping of peroxyl radicals in vitro (Warner et al 1985;Darley-Usmar et al 1989;Alanko et al 1993;Ahotupa et al 1996).…”

Section: Introductionmentioning

confidence: 99%

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The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans

Vasankari

Kujala

Rusko

et al. 1997

European Journal of Applied Physiology

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We investigated the effect of training and racing at moderate altitude (MA) on oxidative stress by assessment of serum diene conjugation (DC) and serum antioxidant potential (TRAP). Nine male top level skiers were studied during a national race (20-30 km) at sea level (SL). Thereafter, the athletes trained for 2 weeks at MA, after which they participated in a 20-30 km race at MA. Venous blood samples were taken before and after the race. The DC, indicating early events of lipid peroxidation, did not change during the race at SL (16 850 vs 15 900 delta Absorbance.l-1) or at MA (19 870 vs. 20 630 delta Abs.l-1). At MA serum DC was higher than at SL both before (25%) and after (30%) the race, the postrace difference being statistically significant (P < 0.05). The TRAP increased during the race at MA (from 1387 to 1943 mumol.l-1, P = 0.016), but not at SL (1713 vs 1582 mumol.l-1). These observations would suggest that the level of oxidative stress might be greater during living, training and racing at MA (higher DC levels). Increased TRAP during the race at MA may indicate that the physiological adaptation to extreme acute oxidative stress was altered. The physiological significance of this observation remains to be investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans

Vasankari

Kujala

Rusko

et al. 1997

European Journal of Applied Physiology

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“…For the analyses of TBA-reactive substances the absorbances were measured at 535 nm [31]. The antioxidant potential of the samples (total peroxyl radical trapping antioxidant potential, TRAP) was estimated by their potency to resist 2,2′-azobis(2-amidinopropane) (ABAP) induced peroxidation [32]. …”

Section: Methodsmentioning

confidence: 99%

Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy

Crohns¹,

Saarelainen²,

Kankaanranta³

et al. 2009

Free Radical Research

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To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and after RT for LC. LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p = 0.016, p < 0.001 and p = 0.027, respectively), but BAL fluid oxidative stress markers were similar. RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p = 0.044, p = 0.034 and p = 0.004, respectively) 3 months after RT. High urate at baseline may compensate against the oxidative stress caused by LC. RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

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“…Studies on the antioxidant activity of resorcinol compar-ing the effect of having two hydroxyl groups in the meta, ortho, or para positions have shown that resorcinol has negligible antioxidant activity compared with catechol and hydroquinone. 67,68 Similarly, resorcinol behaves differently from other dihydroxyphenols for other activities such as prostaglandin and leukotriene formation. While catechol and hydroquinone stimulate production, resorcinol has no effect, or inhibits their formation at higher concentrations, 67 indicating that ARs are unlikely to have an antioxidant effect.…”

Section: Are Alkylresorcinols Antioxidants?mentioning

confidence: 99%

Dietary Alkylresorcinols: Absorption, Bioactivities, and Possible Use as Biomarkers of Whole-grain Wheat- and Rye-rich Foods

2004

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The biologic and chemical properties of alkylresorcinols (ARs) have been reviewed previously, but there has been relatively little research or focus on the importance of ARs in food and diet. ARs represent a significant proportion of the phytochemicals present in wheat and rye, in which they normally exist in concentrations between 300 and 1500 microg/g. ARs are concentrated in the bran fraction of these cereals, and are therefore a significant component of food products rich in whole grain wheat and rye but not in products containing only refined cereal flour. In this review, we discuss the presence of ARs in food, methods of analysis, their absorption and role in the diet in light of their in vitro bioactivities, and their possible use as biomarkers of whole-grain wheat and rye intake.

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Modulation of arachidonic acid metabolism by phenols: Relation to positions of hydroxyl groups and peroxyl radical scavenging properties

Cited by 46 publications

References 29 publications

The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans

The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans

Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy

Dietary Alkylresorcinols: Absorption, Bioactivities, and Possible Use as Biomarkers of Whole-grain Wheat- and Rye-rich Foods

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