Modulation of cell-associated plasminogen activator activity by cocultivation of a stem cell and its tumorigenic descendant.

Abstract

The effect of the presence of one cell type on the plasminogen activator activity of another cell type was studied. The cell types, AC and D, were isolated from a rat neuroblastoma (I. Imada and N. Sueoka, Dev. Biol. 66:97-108, 1978

Laminin interacts with plasminogen and its tissue‐type activator

“…Neuroblastoma cells are known to produce both laminin [19] and PA [20], which at least in some cell lines is t-PA (unpublished). Interestingly, cellassociated PA of tumorigenic rat neuroblastoma cells was suppressed by substratum-attached matrix material of nontumorigenic neuroblastoma cells with little or no PA activity 1201.…”

Effects of plasminogen, streptokinase, and their equimolar complexes with pyruvate kinase on the human neuroblastoma IMR-32 cells

“…uPA is bound to specific receptor (uPAR) and activates PGn, converting it into PA. PA is implicated in proteolysis and tissue degradation. Highly tumorogenic cells have enhanced levels of PGn associated with cells (Liu et al, 1984). PGn itself significantly increases the migration of neuroblasts (Puglianiello et al, 2000).…”