2023
DOI: 10.20944/preprints202305.1870.v1
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Modulation of Cell Response Through the Covalent Binding of Fibronectin to Titanium Substrates

Abstract: Titanium (Ti-6Al-4V) substrates were functionalized through the covalent binding of fibronectin, and the effect of the presence of this extracellular matrix protein on the surface of the material was assessed employing mesenchymal stem cell (MSC) cultures. The functionalization process com-prised the usage of the activation vapor silanization (AVS) technique to deposit a thin film with a high surface density of amine groups on the material, followed by the covalent binding of fi-bronectin to the amine groups u… Show more

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