Modulation of Colonic Motility by Peripheral Neural Inputs to Neurons of the Inferior Mesenteric Ganglion

Weems, William A; Szurszewski, Joseph H.

doi:10.1016/s0016-5085(19)32200-0

Cited by 65 publications

(31 citation statements)

References 14 publications

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“…Mechanosensory fast synaptic input to SMG neurones decreased when intracolonic volume decreased and synaptic input frequency increased when intracolonic volume increased. Previous studies have found that guinea‐pig IMG neurones receive volume‐sensitive mechanosensory input from the colon 19,20 . However, it has not been previously determined whether SMG neurones also receive volume‐sensitive colonic mechanosensory input.…”

Section: Discussionmentioning

confidence: 96%

“…Conversely, circumferential length decreases locally when part of the colon empties either passively or by peristaltic contractions. Results from a previous study suggest that mechanosensory endings of intestinofugal nerves projecting to guinea‐pig PVG neurones are tension receptors, as mechanosensory input to IMG neurones increased when the colon was distended and when colonic contractions were increased, conditions where colonic wall tension probably increases 19 . Indeed, muscle tension receptors, activated by distension or during contraction, have been described throughout the gastrointestinal tract and are generally characterized as either ‘in‐series’ tension receptors or stretch receptors with an ‘in‐parallel’ location 32,33 .…”

Section: Discussionmentioning

confidence: 98%

“…In 19 preparations, the orad and caudad ends of the segment were connected via polyethylene tubing to a Statham (model P23) pressure transducer, a calibrated cylindrical reservoir (30 cm in height, 1.7 mm inner diameter) and a 3‐mL syringe filled with Krebs solution. A detailed description of this pressure‐monitoring system and its properties has been previously published 19,24 . Fluid added or withdrawn from the reservoir altered the fluid height in the reservoir and the basal intraluminal pressure in the colon segment.…”

Section: Methodsmentioning

confidence: 99%

“…Concurrent with these stimuli is an increase in nicotinic cholinergic fast excitatory postsynaptic potentials (F‐EPSPs) recorded in PVG neurones. Increased F‐EPSP activity in guinea‐pig IMG neurones is also associated with spontaneous changes in colonic intraluminal pressure and volume, 19–21 suggesting that mechanosensory intestinofugal nerves project to the IMG function as tension and volume sensors. Collaterals of spinal afferent neurones also make synaptic contacts with PVG neurones 22 .…”

Section: Introductionmentioning

confidence: 99%

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Relationship between colonic motility and cholinergic mechanosensory afferent synaptic input to mouse superior mesenteric ganglion

Miller

Szurszewski

2002

Neurogastroenterology Motil

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Abdominal prevertebral ganglion neurones receive excitatory synaptic input from intestinofugal neurones. To better understand the physiological significance of this input, we examined the relationship between synaptic input to mouse superior mesenteric ganglion (SMG) neurones and intracolonic pressure and volume changes that accompany spontaneous colonic contractions in vitro. Electrical activity was recorded intracellularly from SMG neurones in ganglia attached to a segment of distal colon. The majority of neurones examined received ongoing fast excitatory potentials (F-EPSPs). F-EPSP frequency increased when the colon was distended with fluid and during spontaneous increases in colonic volume that accompanied colonic relaxation. In contrast, F-EPSP frequency in SMG neurones decreased when the colon emptied, and remained at a reduced frequency until the colon refilled and volume increased. Nicotinic blockade of the colon abolished spontaneous colonic contractions and reduced or abolished synaptic input to SMG neurones, suggesting that most of the synaptic input arose from second or higher order neurones. Retrograde labelling identified cell bodies of intestinofugal neurones in myenteric ganglia. Most had short, club-like dendritic processes and appeared uni-axonal. These results show that mechanosensory intestinofugal afferent nerves monitor intracolonic volume changes.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between colonic motility and cholinergic mechanosensory afferent synaptic input to mouse superior mesenteric ganglion

Miller

Szurszewski

2002

Neurogastroenterology Motil

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show abstract

“…Viscerofugal neurons have cell bodies in the gut wall and project to prevertebral ganglia, forming a neural circuit with noradrenergic sympathetic neurons that control motility (Weems and Szurszewski, 1977) and secretion (Quinson and Furness, 2002). Localized distension of the gut potently activates this circuit, resulting in inhibition of gut contractility orally and locally (Kuntz, 1940;Kuntz and Saccomanno, 1944).…”

Section: Introductionmentioning

confidence: 99%