Modulation of convulsive threshold of pentylene tetrazole by zinc

Khanna, N; Garg, Aashima; Sharma, Kuldeep; Khosla, Ritu

doi:10.1007/bf02867963

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Zinc infusion into the hippocampus delayed the development of behavioral seizures in a kindling model of epilepsy [ 193 ], while its oral administration reduced seizure duration and increased the latency of seizures induced by PTZ [ 200 ]. However, a proconvulsive effect was observed with zinc´s intracerebroventricularly pretreatment which decreased the threshold and increased the severity of seizures induced by PTZ [ 201 ].…”

Section: Zinc Signalingmentioning

confidence: 99%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

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Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide. However, despite the continuous development of antiepileptic drugs, over 30% patients with epilepsy progress to drug-resistant epilepsy. For this reason, it is a high priority objective in preclinical research to find novel therapeutic targets and to develop effective drugs that prevent or reverse the molecular mechanisms underlying epilepsy progression. Among these potential therapeutic targets, we highlight currently available information involving signaling pathways (Wnt/β-catenin, Mammalian Target of Rapamycin (mTOR) signaling and zinc signaling), enzymes (carbonic anhydrase), proteins (erythropoietin, copine 6 and complement system), channels (Transient Receptor Potential Vanilloid Type 1 (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have demonstrated a certain degree of efficacy not only in controlling seizures but also in displaying neuroprotective activity and in modifying the progression of epilepsy. Although some research with these specific targets has been done in relation with epilepsy, they have not been fully explored as potential therapeutic targets that could help address the unsolved issue of drug-resistant epilepsy and develop new antiseizure therapies for the treatment of epilepsy.

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Section: Zinc Signalingmentioning

confidence: 99%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

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“…PTZ (Sigma Aldrich, Germany) was used for generating epilepsy model in this study since PTZ is a potent convulsant commonly used to produce epileptiform discharges in animal nervous system (Khanna et al, 1997).…”

Section: Animal Studiesmentioning

confidence: 99%

Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery

Kırımlıoğlu

Yazan

Erol

et al. 2015

International Journal of Pharmaceutics

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Low Dose Zinc Supplementation Beneficially Affects Seizure Development in Experimental Seizure Models in Rats

Kumar

Katyal

Gupta

2014

Biol Trace Elem Res

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The role of zinc in seizure models and with antiepileptic drugs sodium valproate (SV) and phenytoin (PHT) was studied using experimental models of seizures in rats. Male Wistar rats, 150-250 g were administered zinc 2, 20, and 200 mg/kg, orally for 14 days. Sixty minutes after the last dose of zinc, rats were challenged with pentylenetetrazole (PTZ, 60 mg/kg, ip) or maximal electroshock (MES, 70 mA, 0.2 s duration). In another group, SV (150/300 mg/kg, ip) or PHT (40 mg/kg, ip) was administered after 30 min of zinc administration followed by seizure challenge. Zinc pretreatment at all doses had no effect on MES seizures. In PTZ seizures, with the lowest dose used, i.e., 2 mg/kg, a protective effect was observed. Neither the protection offered by the 100 % anticonvulsant dose of SV (300 mg/kg) in PTZ seizures was affected by pre-treatment with zinc nor a combination of subanticonvulsant dose of SV (150 mg/kg) and zinc offer any statistically significant advantage over either drug alone. The combination of phenytoin with zinc had no effect on any of the parameters tested. Apart from this, chronic zinc administration hampered development of chemically (PTZ)-kindled seizures in rats. Zinc supplementation is unlikely to have any undesirable effect when used in epileptics rather it may offer advantage in epileptic and seizure prone patients.

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Modulation of convulsive threshold of pentylene tetrazole by zinc

Cited by 4 publications

References 9 publications

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery

Low Dose Zinc Supplementation Beneficially Affects Seizure Development in Experimental Seizure Models in Rats

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