Modulation of crude oil induced alteration of oxidative stress indices in rat by red palm oil

Abstract

The toxic properties of crude oil were hitherto described. Therefore, several materials are being tested for protective potential counter to petroleum toxicity. This study evaluated the oxidative stress status of rats fed diet incorporating petroleum tainted diet with red palm oil. Four groups with six rats in each group were employed in this study. Rats in group 1 were fed with fish feed only while rats in group 2 were fed with crude oil tainted diet and rats in groups 3 and 4 were fed with contaminated feed that was pre-treated with 4 ml and 8 ml of red palm oil respectively. The rats were exposed to the respective diet for 30 days and had water freely. Thereafter standard analytical methods were used to measure oxidative stress markers in organs/tissues of rats. The results showed that crude oil tainted diet stimulated lipid peroxidation and cause decline in reduced glutathione level, superoxide dismutase and catalase activities in the organ/tissues of rats which were significant (P < 0.05) relative to control. Pre-treatment of the rat diets with red palm oil significantly (P < 0.05) drop lipid peroxidation and increase level of antioxidant markers in the organ/tissues of rats in relation to the values in rats fed with diet tainted with crude oil only. This study has confirmed that red palm oil can evade the oxidative insult elicited by crude oil intoxication in various organs/tissues. Therefore, red palm oil should be made a major dietary component for inhabitants of petroleum producing areas of the world.

Molecular, biochemical and histopathological studies on the ameliorative effect of vitamin C on the renal and muscle tissues of Nile tilapia fish ( Oreochromis niloticus ) affected by the usage of engine oil

“…These results are in agreement with results reported by Kayode Chidimma and Alwell (). A crude oil‐tainted diet stimulated lipid peroxidation and caused a decline in reduced glutathione levels, superoxide dismutase and catalase activities (Achuba, ). Alisi, Ojiako, Osuagwu, and Onyeze () reported that oxidative stress is the primary mode of action of crude oil‐induced renal dysfunction.…”

Pretreatment with Oil Palm Leaf Extracts Confers Protection Against Crude Oil Adulterated Food (COAF)

“…All of the above are similar to the protection conferred on rats by incorporation of powdered oil palm leaf in petroleum-contaminated diets in rats by Achuba. 26; 27 In another development, crude oil diet contamination is often occasioned with the generation of oxidative radicals which is often culminated in the depletion of several enzymatic and non-enzymatic antioxidants and increased lipid peroxidation 6,14,18,19,[25][26][27] and is said to be no different from the one reported in this study (Table 5). However, the use of plant materials by various studies have also been reported to contribute significantly to averting the free radical generating potentials of crude oil-induced oxidative damage to animals.…”

“…[6][7][8] This trend makes food chain petroleum contamination a high-risk burden in areas where ever crude oil exploration occurs as the breakdown of petroleum hydrocarbons have led to the release of free radical generating compounds and activated oxygen, nitrogen, hydrogen, and carbon metabolites into the cells leading to different types of autoimmune disease conditions often manifested as growth impairment, oxidative stress, diabetes, neurodegeneration, and cancer. [9][10][11][12][13][14] In a bid to come to the rescue of man, researchers' all over the world have increasingly advocated the use of natural products as alternatives to synthetic adjuvants against toxic compounds as these synthetics aside being expensive may have some element of contribution to counter drug reactions occurring in biological systems. [15][16][17] Some of the most recent adjuvants used include Vernonia amygdalina extracts, [18][19][20] Monodora myristica extracts, [21][22][23] Moringa oleifera extracts, 24,25 © 2020 the authors.…”

Effects of Siam Weed (Chromolaena odorata) Leaf Extract on Crude Oil-induced Toxicity

“…Biochemical consequences of consuming hydrocarbon tainted diet have been voraciously reported [11,37,38,39,40]. Moreover, one major health implication of exposure to crude petroleum is decrease in body weight [4].…”